Analysis of mouse models of premature glial senescence

项目摘要 中枢神经系统胶质细胞，包括少突胶质细胞、星形胶质细胞和小胶质细胞，调节神经元功能。尽管我们知道的很多 关于它们在发育和成人中枢神经系统中的重要性，关于神经胶质细胞的年龄仍然存在知识空白。 会导致再生髓鞘衰竭和神经变性。这与年龄相关的神经退行性变尤其相关。 疾病，如继发性进行性多发性硬化症(MS)、阿尔茨海默病(AD)和帕金森病(PD) 其中，中枢神经系统内的胶质细胞功能障碍和慢性炎症是常见的特征。为了充分理解 衰老的神经胶质细胞对中枢神经系统功能的影响，本项目的目标是表征新的中枢神经系统神经胶质细胞衰老模型。 并检测其对中枢神经系统功能和修复的影响。

Project Summary CNS glial cells, including oligodendrocytes, astrocytes and microglia, regulate neuronal function. Although much is known about their importance in the developing and adult CNS, a gap in knowledge remains with regards to how aged glia contribute to remyelination failure and neurodegeneration. This is particularly relevant to age related neurodegenerative disorders, such as secondary progressive multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD) in which glial dysfunction and chronic inflammation within the CNS, are common features. In order to fully understand the impact of aged glia on CNS function, the goal of this project is to characterize novel models of CNS glial senescence in mice and examine their impact on CNS function and repair.