Integrated Small Animal Imaging Research Resource

摘要 对癌症的小动物模型进行成像已成为癌症研究中必不可少的组成部分。这个 综合小动物影像研究资源(ISAIRR)展示了其广泛的用途和 在推进乳房、肺、前列腺、卵巢、头颈、胰腺、结直肠、 和脑癌。不断发展的成像技术也使不同但互补的 用于评估潜在生物学和机制、改进诊断和检测的成像方法，以及 监测癌症治疗的效果。为了充分利用这一快速变化的成像环境，以及 为了提供更广泛的成像功能和服务，iSAlRR现在提供更广泛的 小动物体内成像和组织/器官体外成像的成像方式和技术 提高操作效率和成本效益的标本。ISAIRR现在包括以下内容 次核心：1)磁共振成像和光谱(MRIS)；2)光学成像(OI)； 3)microPET/SPECT/CT成像，在此周期中增加了图像和数据分析组件；以及 4)成像化学。CCSG没有为成像化学服务申请资金。影像 化学分核成立于2015年，利用UCCCC发展基金，带来了独特的 向我们的用户提供能力和专业知识，包括专门设计的造影剂，并与 新的回旋加速器设施和开发的放射化学计划，使独特的成像方法。 在目前的供资期间，对综合审查制度进行了战略性调整，以更好地支持正在进行的和 未来的研究。新的技术总监和扩大的教职员工加强了核心领导力 代表我们核心用户和服务不断变化的需求的监督委员会。影像 兽医技术支持分核心被解散，并采用了更有效的模式。训练有素 兽医技术人员的努力根据需要分布在所有医疗模式中，并增加了对 操作员。9.4T核磁共振扫描仪最近进行了升级，并计划扩大microPET/ SPECT/CT成像服务和能力。展望未来，超声成像亚核将是 建立了独立和辅助使用的收费服务结构，并可供用户使用(否 CCSG申请的资金)。经过内部审查并遵循用户的要求，图像分析组件 之前包含在UCCCC图像计算、分析和存储库核心(ICAR)中 进入ISAIRR。更具体地说，它已被并入microPET/SPECT/CT亚核。是这样的 整合通过在以下方面提供更有机、更具包容性的服务来提高这一次核心的效率 分子成像。

ABSTRACT Imaging small animal models of cancer has become an essential and integral part of cancer research. The Integrated Small Animal Imaging Research Resource (iSAIRR) has demonstrated its broad usage and applications in advancing research in breast, lung, prostate, ovarian, head and neck, pancreatic, colorectal, and brain cancer. Evolving imaging technologies have also made available different, but complementary, imaging methods for assessing underlying biology and mechanisms, improving diagnosis and detection, and monitoring effects of cancer therapies. To take full advantage of this rapidly changing imaging landscape, and to provide a wider spectrum of imaging capabilities and services, the iSAlRR now offers a broader spectrum of imaging modalities and techniques for in vivo imaging of small animals and ex vivo imaging of tissue/organ specimens with improved operational efficiency and cost effectiveness. The iSAIRR now includes the following Subcores: 1) Magnetic Resonance Imaging and Spectroscopy (MRIS); 2) Optical Imaging (OI); 3) microPET/SPECT/CT imaging, with the image and data analysis components added in this cycle; and 4) Imaging Chemistry. CCSG funds are not requested for the Imaging Chemistry services. The Imaging Chemistry Subcore was established in 2015 using UCCCC Developmental Funds, and brings distinctive capabilities and expertise to our users, including specifically designed contrast agents, and collaborates with the new Cyclotron Facility and developing radiochemistry program enabling unique imaging approaches. During the current funding period, the iSAIRR has been strategically restructured to better support ongoing and future research. Core leadership has been enhanced with new technical directors and an expanded Faculty Oversight Committee representing the changing needs of our users and services of the Core. The Imaging Veterinary Technology Support Subcore was dissolved and a more efficient model has been adopted. Trained veterinary technicians’ effort is distributed across all modalities as needed, with an increased contribution from operators. The 9.4T MRI scanner was recently upgraded, and there are plans to expand the microPET/ SPECT/CT imaging services and capabilities. Going forward, an Ultrasound Imaging Subcore will be established, and available to users with a fee-for-service structure for independent as well as assisted use (no CCSG funds requested). After an internal review and following users’ requests, the image analysis component previously included in the UCCCC Image Computing, Analysis, and Repository Core (ICAR), was incorporated into ISAIRR. More specifically, it has been incorporated into the microPET/SPECT/CT Subcore. Such integration has enhanced the efficiency of this Subcore by providing more organic and inclusive services in molecular imaging.