Factors Associated with Mailed Return of Self-Sampling for Human Papillomavirus (HPV) Testing

项目摘要/摘要 宫颈癌对低收入和从未/未做过筛查的妇女的影响不成比例(从不 已筛选或未筛选)。低收入女性在结构和个人内部都存在障碍， 筛查可能会阻止他们获得基于提供者的筛查。尽管HPV检测现在是 被USPSTF指南接受，它只被认可用于提供者收集的样本。人乳头瘤病毒的自我采样 检测是一种妇女采集自己宫颈阴道样本的方法，是一种可行和可接受的方法。 基于提供者的宫颈癌筛查的替代方案。HPV自我采样很可能作为一种 由于其对提供者收集的HPV样本具有相当的敏感性，因此未来将在美国选择筛查选项， 可接受性，以及接触到从不/未接受筛查的人群的潜力。自我抽样可能会克服 低收入和低收入妇女在基于提供者的宫颈癌筛查中遇到的障碍 从未/未进行过筛查，并提供了访问筛查的便捷方式。研究测试邮寄的HPV试剂盒， 然而，研究表明，30%-50%的女性不会退回邮寄的HPV试剂盒。在广泛传播之前 实施后，需要进行研究，以确定邮寄HPV的寄件人和不寄件人的特征 自我采样工具包。这项描述性研究的目的是确定与邮寄退货有关的因素 使用创新扩散理论概念的HPV自检试剂盒(优势、兼容性、 复杂性和自我效能感)，同时控制社会人口、医疗保健和健康行为变量 在一群低收入和从未/未接受过筛查的女性中。 这项横断面研究的数据将在研究时收集来自妇女(n=200)的同意。 储藏室。自我采样工具包将在同意后一周内邮寄到妇女家中，妇女将 有4个星期的时间退还试剂盒，被视为“退货者”。在收集的数据之间的关系 基线同意(创新的属性--优势、兼容性、复杂性和自我效能)和回报 将分析邮寄的自我采样工具包(y/n)。 这项研究的结果将提供与将自我采样试剂盒退回给 更好地了解返回者和不返回者的特点。该项目的结果将有助于指导 低收入、从未/未筛查人群中HPV自我采样的实施 抽样可能最有可能受益。这项研究将为申请人的长期目标提供基础 通过提高宫颈癌筛查率来降低宫颈癌的发病率和死亡率 一项创新技术，用于HPV检测的自我采样。此外，此应用程序还反映了对 NRSA个人研究员儿童保育费用行政补编-非21-070。

Project Summary/Abstract Cervical cancer disproportionately affects women who are low-income and never/underscreened (never screened or under screened). Women who are low-income have structural and intrapersonal barriers to screening that may prevent them from obtaining provider-based screening. Although HPV testing is now accepted by USPSTF guidelines, it is only endorsed for provider-collected sampling. Self-sampling for HPV testing, a method for women to collect their own cervico-vaginal sample, is a feasible and acceptable alternative to provider-based cervical cancer screening. HPV self-sampling is likely to be implemented as a screening option in the US in the future due to its comparable sensitivity to provider-collected HPV samples, acceptability, and potential to reach populations who are never/underscreeners. Self-sampling may overcome barriers to provider-based cervical cancer screening experienced by women who are low-income and never/underscreened and provide a convenient way to access screening. Studies testing mailed HPV kits, however, have demonstrated that 30-50% of women do not return a mailed HPV kit. Prior to widespread implementation, research is needed to identify characteristics of returners and non-returners of mailed HPV self-sampling kits. The purpose of this descriptive study is to identify factors associated with mailed return of HPV self-sampling kits using concepts from the Diffusion of Innovations Theory (advantages, compatibility, complexity, and self-efficacy) while controlling for sociodemographic, healthcare, and health behavior variables in a group of low-income and never/underscreened women. Data for this cross-sectional study will be collected at time of study consent from women (n=200) at a food pantry. Self-sampling kits will be mailed to the women’s home within one week of consent, and women will have 4 weeks to return the kit to be considered “returners”. The relationship between the data collected at baseline consent (attributes of innovation-advantages, compatibility, complexity, and self-efficacy) and return of the self-sampling kit via mail (y/n) will be analyzed. The results of this study will provide knowledge about factors associated with return of self-sampling kits to better understand the characteristics of returners and non-returners. Results of this project will help guide implementation of HPV self-sampling in populations who are low-income and never/underscreened whom self- sampling may most likely benefit. This study will provide a foundation for the applicant’s long-term goal of reducing morbidity and mortality from cervical cancer through increasing cervical cancer screening rates with an innovative technology, self-sampling for HPV testing. In addition, this application reflects a request for the Administrative Supplement for Childcare Costs for NRSA Individual Fellows NOT-ON-21-070.