Effects of Acculturation on Gestational Biology in Mexican-American Pregnant Women

摘要 这项提议寻求额外的工资支持，以弥补因以下原因而错过的职业发展活动 校园和日托关闭导致新冠肺炎中断。研究计划没有任何拟议的变化。 研究综述。一个重要的问题涉及流行病学观察的根本原因(S) 拉丁裔移民的健康状况(特别是肥胖)随着时间的推移和世代的变化呈现出逐渐下降的趋势。我 表明肥胖率的代际攀升可能是与文化适应相关的结果 女性的生理变化。在怀孕期间，这些变化可能会传递给下一代(胎儿) 影响后代决定肥胖(肥胖症)易感性的表型。必要的一步， 研究这一假说是为了确定文化适应是否与以下各方面的变化有关 妊娠生物学涉及肥胖症的胎儿程序化。此外，我还建议， 文化适应--健康文献可能与文化适应结构的可操作性的局限性有关 没有考虑到社会语境的调节作用。这个项目的发现将揭示新的信息 关于弱势人群的健康状况，这可能导致早期确定高危人群的新途径 个人和预防战略，以限制劣势和健康状况不佳的代际延续。我是 正在按计划在授权期结束前完成所有最初的K01项目目标。我已经收购了NIDDK R03 在我的K01期间发表了12篇论文，还有2篇在同行评议中。 环境摘要。在加州大学洛杉矶分校，我有自己的生物实验室，位于生命科学大楼， 在那里我可以处理和存储在我的K01研究活动中收集的生物样本。总部设在加州大学洛杉矶分校 在人类学和考辛斯心理神经免疫学中心，我有无数的资源，包括 由高级调查人员组成的跨学科团队，提供智力生产的环境，研究人员， 办公室和实验室设施，以及人类生物学最新方法的体验式教育。 候选人摘要。我主要对社会生态的生物嵌入概念感兴趣。 条件，以及胎儿健康和疾病的起源。我的职业目标是成为一名独立人士 R01资助的人类发育生物学研究员，解决与如何 个体的社会和环境生态影响生物系统，以及生物之间的联系 世代影响与慢性病风险相关的动态平衡机制的发展。 职业发展计划摘要。我在K01奖的第一年到第二年进行了正式的课程学习。 句号。我得到了一个由教授领导的各自领域的知名专家团队的指导。巴提克·瓦德瓦 (K-AWARD从UCI过渡到UCLA之前)和Christine Dunkel Schetter(过渡后)，该领域的领导者 关于产前应激生物学和胎儿疾病起源的研究，并从一组 其他大学的杰出教职员工。

ABSTRACT THIS PROPOSAL seeks additional salary support to compensate for career development activities missed due to COVID-19 disruptions from campus and daycare closures. There are no proposed changes to the research plan. RESEARCH SUMMARY. An important issue relates to the underlying cause(s) of epidemiologic observations that Latino immigrants exhibit a progressive decline in health (particularly obesity) over time and across generations. I suggest that the intergenerational escalation in obesity rates could be a consequence of acculturation-related biological changes in women. During pregnancy, these changes may be transmitted to the next generation (fetus) to influence offspring phenotypes that determine susceptibility for obesity (adiposity). A necessary step towards investigating this hypothesis is determining whether acculturation is associated with changes in aspects of gestational biology involved in fetal programming of adiposity. Also, I suggest that inconsistencies in the acculturation-health literature may relate to limitations of operationalization of the acculturation construct and failure to consider the modifying role of social context. Findings from this project will reveal new information about health status of vulnerable populations, which could lead to new avenues for early identification of at-risk individuals and prevention strategies to limit intergenerational perpetuation of disadvantage and poor health. I am on track to complete all the original K01 project aims by end of the award period. I already acquired NIDDK R03 funding and published 12 papers during my K01 period, with 2 more in peer review. ENVIRONMENT SUMMARY. At UCLA, I have my own biological laboratory located in the Life Sciences building, where I can process and store biosamples collected in my K01 research activities. Based in the UCLA Department of Anthropology and the Cousins Center for Psychoneuroimmunology, I have myriad resources, including an inter-disciplinary team of senior investigators to provide an intellectually productive environment, research staff, office, and laboratory facilities, and experiential education in state-of-the-art methods in human biology. CANDIDATE SUMMARY. I am primarily interested in the concepts of biological embedding of socio-ecological conditions, and the fetal origins of health and disease paradigm. My career goal is to become an independent investigator in human developmental biology with R01 funding, addressing key questions related to how an individual’s social and environmental ecology influences biological systems, and how biological links between generations affect the development of homeostatic mechanisms associated with chronic disease risk. CAREER DEVELOPMENT PLAN SUMMARY. I conducted formal coursework during Years 1-2 of the K01 award period. I am mentored by a team of prominent experts in their respective fields, led by Profs. Pathik Wadhwa (pre-transition of K-award from UCI to UCLA) and Christine Dunkel Schetter (post transition), leaders in the field of prenatal stress biology and fetal origins of disease, and receive specialized short-term training from a team of distinguished faculty at other universities.