A multidimensional study on articulation deficits in Parkinsons disease

项目摘要 构音障碍是一种运动性言语障碍，影响个体的各种病因。 仅帕金森病（PD）就影响了美国近100万人，构音障碍 在发病后的头两年内，大约90%的这些个体会发生这种情况。的 与PD相关的构音障碍的特征是运动减少，这已经被支持 在PD患者中发现唇、舌和下颌运动减少。但委员会仍 不清楚运动减退性构音障碍是否会导致所有关节的整体减少，或者是否是特定的 这种疾病会对发音器官造成损害。此外，我们并不完全了解 影响语音清晰度的因素。具体地说，我们对发音知之甚少- 语音清晰度的运动学相关性。这个缺失的环节是至关重要的理解，因为发音 无论病因如何，缺陷是构音障碍的普遍特征。拟定研究 提供了一个运动学，声学和感性的特点，在扬声器的相关调查 和神经系统健康的说话者。本研究的目的是（1）考察知觉， 声音，和发音特异性运动缺陷的扬声器与PD和（2）了解 发音运动和言语感知测量之间的关系。具体目标1 将研究帕金森病患者和神经健康者之间的组差异 扬声器使用知觉，声学，和发音特定的运动学措施。我们 假设知觉、听觉和与舌头相关的运动学测量将区分 来自神经健康的说话者的PD患者。Specific Aim 2将模拟语音 可懂度（具体目标2a）和发音精度评级（具体目标2b），使用选定的 声学和运动学测量。我们假设声学测量将是 比运动学测量更强的语音清晰度预测因子，因为它们都是 从语音信号。此外，我们假设所选择的运动学测量可以 与语音清晰度相比，与清晰度等级的关系更强。本研究 这是实现我们推进构音障碍管理策略的长期目标的必要步骤。的 主要结果将是解释性模型，确定声学和发音相关的 语音清晰度和发音精确度。这项研究对以下方面具有重要意义 制定针对特定发音器官的构音障碍管理策略， 构音障碍管理策略。

PROJECT ABSTRACT Dysarthria is a motor speech disorder that affects individuals with a variety of etiologies. Parkinson’s disease (PD) alone affects nearly one million individuals in the U.S., with dysarthria developing in approximately 90% of these individuals within the first two years of onset. The dysarthria associated with PD is characterized by reduced movement, which has been supported by findings of reduced lip, tongue, and jaw movement in speakers with PD. However, it remains unclear if hypokinetic dysarthria causes a global reduction across all articulators, or if specific articulators are disproportionally affected by the disease. Further, we do not fully understand the factors contributing to speech intelligibility. Specifically, little is known about the articulatory- kinematic correlates of speech intelligibility. This missing link is vital to understand, as articulation deficits are a universal characteristic of dysarthria, regardless of etiology. The proposed study provides a linked investigation of kinematic, acoustic, and perceptual characteristics in speakers with PD and neurologically healthy speakers. This research aims to (1) examine the perceptual, acoustic, and articulator-specific movement deficits in speakers with PD and (2) understand the relationship between articulatory movement and measures of speech perception. Specific Aim 1 will examine the group differences between speakers with PD and neurologically healthy speakers using perceptual, acoustic, and articulator-specific kinematic measures. We hypothesize the perceptual, acoustic, and tongue-related kinematic measures will differentiate individuals with PD from neurologically healthy speakers. Specific Aim 2 will model speech intelligibility (Specific Aim 2a) and ratings of articulatory precision (Specific Aim 2b) using selected acoustic and kinematic measurements. We hypothesize that the acoustic measures will be stronger predictors of speech intelligibility than the kinematic measures, as they are both derived from the speech signal. Further, we hypothesize the selected kinematic measures may demonstrate a stronger relationship to articulation ratings than speech intelligibility. This study is a requisite step towards our long-term goal of advancing dysarthria management strategies. The primary outcome will be explanatory models that identify acoustic and articulatory correlates of speech intelligibility and articulatory precision. This study has important implications for developing articulator-specific dysarthria management strategies to supplement universal dysarthria management strategies.