Green deal inspired correlative imaging-based characterization for safety profiling of 2D materials (ACCORDs)

作为二维纳米材料(NMS)的代表，ACCODS将为石墨烯家族材料(GFMS)的整体相关性评估开发一个基于成像的表征框架(ACCODS框架)，以评估和预测2D纳米材料的健康和环境风险。ACCODS框架将实施过去或正在进行的H2020项目或OECD内部提出的安全和可持续设计(SSBD)战略，将基于低、中、高分辨率物理-化学-生物成像的方法与非成像方法以分级方法相关联。ACCODS将提供ACCODS框架和用户指南、新的基于成像的表征方法(3-6种方法)、体外参考测试(最多三种新测试)、针对不同矩阵的新参考2D NMS(最多三种)、用于公平数据共享和图像重复使用的新的最低信息报告指南以及包含参考图像的图集，用于诊断GFMS/GFM产品的安全性。新的指导方针和标准建议将提交给标准化机构，以允许创建可供监管使用的产品。ACCODS的新奇之处在于将基于医学成像的诊断原理转化为2D材料危险诊断。协议将加速航空、海洋建筑、无人机生产、柔性电子产品、光伏、光催化和基于印刷油墨的传感器领域的工业部门。向石墨烯行业建议的Value Contents是实用、简单、基于成像的工具，可用于生产线旁的GFM质量监控，并有可能在诊断出危险时与先进的高分辨率成像表征方法相关联，即偏离控制(基准值)。协议框架和工具将通过解决“石墨烯：欧洲领先”的主题，以及2022年2月2日发布的新的欧洲标准化战略，为欧洲绿色协议做出贡献。

ACCORDs will develop an imaging-based characterization framework (ACCORDs framework) for the holistic correlative assessment of Graphene Family Materials (GFMs) as a representative of 2D nanomaterials (NMs) to assess and predict 2D NMs health and environmental risks. The ACCORDs framework will operationalise safe and sustainable by design (SSbD) strategies proposed in past or ongoing H2020 projects or within OECD by correlating low-, medium-, and high-resolution physico-chemical-biological imagingbased methods with non-imaging methods in a tiered approach. ACCORDs will deliver the ACCORDs framework and user guidance, new imaging-based characterisation methods (3-6 methods), reference in vitro tests (up to three new tests), new reference 2D NMs (up to three) for different matrices, a new minimum information reporting guideline for FAIR data sharing and reuse of images as well as an atlas with reference images for diagnostics of compromised safety of GFMs / GFM products. The new guidelines and standard proposals will be submitted to standardisation bodies to allow creation of regulatory ready products. The novelty of ACCORDs is in translating the principles of medical imaging-based diagnostics to 2D material hazard diagnostics. ACCORDs will accelerate industrial sectors in the area of aviation, marine construction, drone production, flexible electronics, photovoltaics, photocatalytics and print inks-based sensors. The value ACCORDs proposes to the graphene industry are practical, easy, imaging-based tools for GFM quality monitoring next to the production line with a possibility to be correlated with advanced high-resolution imaging characterization methods in case hazard i.e. deviation from controls (benchmark values) are diagnosed. The ACCORDs framework and tools will contribute to the European Green Deal by addressing the topic: “Graphene: Europe in the lead” and to a new European strategy on standardization, released on 2nd February, 2022.