In vivo Fractional Blood Volume: Contributions to Renal BOLD MRI.

我们的实验室率先使用血氧水平依赖（BOLD）MRI肾脏作为一种方法， 评估其氧合状态世界各地的一些研究人员已经验证了这项技术。 然而，它仍然是一种定性指标，其对氧合的特异性尚未得到验证。即使它 血液体积分数（被血液占据的组织的分数）存在作用 在BOLD MRI中，由于缺乏数据，一直默认其很小或不存在。 然而，最近的发展使我们能够使用血池造影剂测量区域fBV。 在这里，我们想第一次测量人类肾脏中的区域fBV，看看（i）它是否与人类肾脏中的不同。 皮质和髓质;（ii）是否髓质fBV减少时，管理呋塞米建议，最近 大鼠肾脏中的数据;以及（iii）慢性肾病（CKD）个体中局部fBV是否减少。 如果拟议的研究是成功的，它可能支持使用fBV作为一个独立的成像标记物。在 此外，这些数据将对肾脏BOLD MRI数据的解释产生重大影响。

Our laboratory has pioneered the use of blood oxygenation level dependent (BOLD) MRI the kidneys as a way of evaluating its oxygenation status. Several investigators around the world have validated the technique. However, it remains as a qualitative measure and its specificity to oxygenation is not validated. Even though it is known theoretically that a role exists for the fractional blood volume (fraction of the tissue occupied by blood vessels) in BOLD MRI, with the lack of data it has been tacitly assumed to be either small or non-existent. However, recent developments allow us to measure regional fBV using blood pool contrast agents. Here, we want to for the first time measure regional fBV in human kidneys and see (i) whether it is different in cortex and medulla; (ii) whether medullary fBV reduces when administering furosemide as suggested by recent data in rat kidneys; and (iii) whether regional fBV is reduced in individuals with chronic kidney disease (CKD). If the proposed study is successful, it may support the use of fBV as an independent imaging marker. In addition, the data will have a significant impact on the interpretation of renal BOLD MRI data.