Administrative Core

摘要 行政核心将作为一个综合的、确定优先事项的联合体建立 包括主要研究者（PI/PD）、内部CETR领导团队和科学顾问 在NIAID的方案参与下，该委员会（SAC）加强了潜在的产品成果。的 管理职能旨在提供行政支持，促进个人的成功 项目，促进保障职能和资源的有效整合和配置，激发 CETR成员之间的科学交流，从而确保整个CETR计划实现其 目标.管理核心将由中心PI大卫柏林博士监督，他将由一名 经验丰富的行政人员和财务总监，协调和管理所有行政职能。最好地 推进CETR目标，行政核心将协调项目领导人及其 合作者（和分包商）、科学/发现核心主管和SAC成员。这些会议 旨在通过发现矩阵推进化合物，实现及时和客观的“去，不去” 决策。管理核心还将促进与SAC的年度审查会议， 参观NIAID。它将制作并向NIH提交年度进展报告，并协调研究 出版物、会议介绍、报告和新闻稿。最后是与专利局的联络 和许可组，负责保护CETR产生的知识产权，以及许可 机会管理核心将执行以下具体目标：1）建立一个高效的 为项目负责人和核心主管提供基本监督和指导的管理结构， 有效地整合了科学顾问委员会作为发现/开发的战略顾问 过程，促进科学交流; 2）最大限度地分配资源，优先考虑化合物 通过建立“去，不去”决策和资源分配的关键指标， 支持项目负责人和核心主管的密切互动，并安排定期审查; 3）制定 一个有效的战略，以评估年终项目业绩，编写中期和年终报告， a酌情补充项目; 4）协调出版物、成果介绍和新闻稿 （五）建立内部组织结构， 材料转让协议、保密、知识产权备案和许可机会的物流 并制定解决冲突和其他业务问题的管理计划。

Abstract The Administrative Core (Admin Core) will be established as an integrated, priority-setting consortium involving the Principal Investigator (PI/PD), an internal CETR leadership team, and a Scientific Advisory Committee (SAC) with programmatic involvement from NIAID to enhance potential product outcome. The management function is designed to provide administrative support that facilitates the success of individual Projects, promotes effective integration and allocation of support functions and resources, and stimulates scientific exchange between CETR members, thus ensuring that the overall CETR program achieves its objectives. The Admin Core will be overseen by the Center PI, Dr. David Perlin, who will be supported by a seasoned administrator and financial director to coordinate and manage all administrative functions. To best advance CETR objectives, the Admin Core will coordinate regular meetings of Project Leaders and their collaborators (and subcontractors), scientific/discovery Core Directors, and SAC members. The meetings are designed to advance compounds through the discovery matrix enabling timely and objective “go, no-go” decision making. The Admin Core will also facilitate an annual review meeting with the SAC, and reverse site visit at NIAID. It will produce and submit the annual progress report to the NIH, and it will coordinate research publications, meeting presentations, reports and press releases. Finally, it will be the liaison with the Patent and Licensing group for the protection of intellectual property generated by the CETR, as well as licensing opportunities. The Admin Core will execute the following Specific Aims: 1) establish a highly efficient management structure that provides essential oversight and guidance for Project Leaders and Core Directors, effectively integrates the Scientific Advisory Committee as strategic advisors in the discovery/development process, and promotes scientific exchange; 2) maximize allocation of resources and prioritize compound development by establishing critical metrics for “go, no-go” decision making and resource allocations by supporting close interactions of Project Leaders and Core Directors and scheduling regular reviews; 3) develop an effective strategy to assess year-end Project performance, prepare interim and year-end reports, and recruit a Supplemental project, as appropriate; 4) coordinate publications, presentations of results, and press releases arising from the output of these studies; and 5) establish an internal organizational structure that addresses logistics for material transfer agreements, confidentiality, intellectual property filings and licensing opportunities and negotiations; and develop a managerial plan for conflict resolution and other operational issues.