Decoding the enigmatic biology of human gamma-delta T cells

免疫系统检查我们的身体，检查分子，这些分子发出信号，表明一切是否正常。T细胞是这一过程的中心，并利用它们的受体来监测这些分子信号。T细胞的一个特殊亚群被称为γ - δ T细胞，对检测感染和癌症至关重要，但人们对它们的基本生物学知之甚少。这个项目旨在解开这个难以捉摸的生物学。目的是为了理解。γ - δ T细胞亚群之间功能的多样性；T细胞受体的多样性以及这些受体检测到的分子。这项工作对于理解γ - δ T细胞免疫学至关重要，如果我们最终希望利用它来改善人类健康，这是至关重要的。

The immune system surveys our body examining molecules that signal whether or not everything is ok. T cells are a central to this and use their receptors to monitor these molecular signals. A specialised subset of T cells known as gamma-delta T cells are critical to detecting infection and cancer, yet their fundamental biology is poorly understood. This project aims to unravel this elusive biology. The aims are to understand 1. The diversity in function between gamma-delta T cell subsets, and 2. The diversity in gamma-delta T cell receptors and the molecules that these receptors detect. This work is essential for understanding gamma-delta T cell immunology which is critical if we ultimately wish to harness this to improve human health.