Intergenerational health impacts of interpersonal and community-based violence: From childbirth to childbearing

项目摘要 这项建议概述了为期3年的博士后培训奖学金，旨在为受训人员准备 在一所主要研究型大学担任独立研究员。研究和培训计划是基于 关于申请人对研究健康的社会决定因素以及暴力和社会压力是如何 其结构和体现方式可能会使健康不平等现象代代相传。她之前的职业生涯 研究生院参与了针对少数群体的应用混合方法研究和公共政策宣传。 在东南亚经历剥夺公民权和侵犯人权的情况。在她的研究生培训期间 她接受了流行病学、人口学和社会研究方法方面的高级培训，以便研究 人口健康差距的结构性原因。在她的论文中，她设计并完成了自己的论文 在泰缅边境对难民、移民和当地居民进行调查，以便更好地评估 产妇和儿童健康如何受到与武装冲突、种族主义、军事和保健有关的产妇生活史的影响 警察的监视，以及其他形式的暴力。她招募了800多对母子，其中520对 完成每个调查部分：深入的母亲访谈、人体测量和头发样本收集。 她提出的博士后研究和培训使用的是她已经收集的数据，以及 来自东南亚和美国的互补数据，使她能够更仔细地研究暴力是如何 可通过社会风险链和相关的生物机制影响孕产妇和儿童健康。她 将模拟由暴力触发并可能导致不良生育结果的孕产妇风险链，从 从分娩到生育，正如在冲突中收集的生活事件史中所表明的那样--以及 泰缅边境受流离失所影响的人口(目标1)及其测量结果 预期在家庭形成高峰期的美国代表队列中(目标2)。她将专注于更多 通过研究母亲生物应激作为过去暴力和不良生育结果的中介的密切关系 童年和青少年暴力如何塑造成人应激和慢性炎症的生物标记物 根据菲律宾的队列数据，对怀孕前和怀孕期间的母亲进行调查(目标3)。 拟议的培训计划涉及研究人类应激的生物和心理模型以及 健康生理学，以及生物测试和应激生物标志物数据分析方面的实践培训，依次为 完成拟议的目标，并为独立的研究生涯做准备。具体的培训目标 包括：(1)加深对应激生理和体现的生物社会途径的理解；(2)拓宽 具有现场纵向测量数据收集和分析的专业知识；(3)学习现场应力数据 和生物标本采集及相关实验室技术和分析；(4)建立出版物记录， 为教师职位做准备，并为未来的研究写助学金。

Project Summary This proposal outlines a 3-year post-doctoral training fellowship, designed to prepare the trainee for a career as an independent researcher at a major research university. The research and training plan are based on the applicant's interest in studying social determinants of health and how violence and social stress are structured and embodied in ways that can perpetuate health inequities across generations. Her career before graduate school involved applied mixed method research and public policy advocacy for minority populations experiencing disenfranchisement and human rights violations in Southeast Asia. During her graduate training she gained advanced training in epidemiologic, demographic, and social research methods in order to study structural causes of population health disparities. For her dissertation, she designed and completed her own survey at the Thai-Myanmar border among refugees, migrants, and local residents in order to better evaluate how maternal and child health is shaped by maternal life histories related to armed conflict, racism, military and police surveillance, and other forms of violence. She recruited over 800 mother-child pairs, 520 of which completed each survey component: in depth mother interviews, anthropometry, and hair sample collections. The post-doctoral research and training that she proposes uses data she has already collected, along with complementary datasets from Southeast Asia and the US, that allow her to examine more closely how violence can influence maternal and child health, through social chains of risk and related biological mechanisms. She will model maternal chains of risk triggered by violence and potentially leading to adverse birth outcomes, from childbirth to childbearing, as they are indicated in life event histories collected among conflict- and displacement-affected populations at the Thai-Myanmar border (Aim 1) and as they have been measured prospectively in a US-representative cohort at the peak of family formation (Aim 2). She will focus in more closely on maternal biological stress as a mediator of past violence and adverse birth outcomes by examining how childhood and adolescent violence shape adult biological markers of stress and chronic inflammation among mothers before and during pregnancy based on cohort data from the Philippines (Aim 3). The proposed training plan involves the study of human biological and psychological models of stress and health physiology, along with practical training in the bioassays and analysis of stress biomarker data, in order to complete the proposed aims and prepare for an independent research career. Specific training goals include: (1) Deepen understanding of stress physiology and biosocial pathways of embodiment; (2) Broaden expertise with field-based longitudinal survey data collection and analysis; (3) Learn field-based stress data and biospecimen collection and related lab techniques and analyses; and (4) Establish publication record, prepare for faculty position, and write grants for future research.