Administrative Core A

项目摘要/摘要(核心A，Portnoy) 核心A的目的是确保科学进步，并通过提供有效的科学 以及对该项目的行政领导和财务监督。这些目标将会实现 通过在所有项目和核心参加的每月会议上广泛审查科学进展 来自湾区各地的计划和附属实验室小组；小组举行的较小会议；以及 分享对潜在博士后研究员的采访。科学方向和研究成果将以 来自P01内部调查人员的密集、建设性的批评以及来自外部的定期评估 科学顾问委员会。我们坚信，我们由Core A推动的广泛协作方法 是独一无二的。事实上，这个项目代表了湾区调查人员研究的核心群体 细胞内病原体和先天免疫。具体目标是：1)开展科学管理 进展；2)建立并聘请外部咨询委员会审查科学进展；以及3)实施 财务管理和行政支持。为了促进调查人员之间的互动，两个小时 加州大学伯克利分校将继续每月举行联合实验室会议。这些每月的会议包括 来自两个不同实验室的介绍性讨论和两个科学报告。考虑到可能的限制 关于冠状病毒，如有必要，我们将在会议上使用电话会议选项。 外部科学顾问委员会由加州大学洛杉矶分校的杰弗里·F·米勒博士担任主席，将提供严格和 对项目的科学方向、研究成果和进展进行一致的评估。核心A将 促进外部董事会和调查人员之间以及项目之间的关系 领导人本人，他们将每月在项目主任办公室会面一次，时间为2小时。波特诺伊， 万斯、考克斯和斯坦利实验室都有每周一次的实验室会议，以审查各自正在进行的研究 实验室。除了P01人员和其他湾区实验室的月度会议外，还有许多其他 为调查人员和受训人员提供互动、交流思想和发言的机会，包括每周一次的 免疫学和病因学部“正在进行的研究”会议周一中午举行，有2人参加 来自2个不同实验室的演讲者；传染病和疫苗小组关于 周一上午10点，大多数演讲者来自当地实验室；微生物生物学系列研讨会，于 周三中午，来自美国和世界各地的演讲者。最后，我们有一个年度 与加州大学旧金山分校联合举办的Asilomar免疫学务虚会。核心A作为行政核心 对于P01来说，它一直是我们成功的关键因素。

Project Summary/Abstract (Core A, Portnoy) The purpose of Core A is to ensure scientific progress and promote synergy by providing effective scientific and administrative leadership and financial oversight to the program. These objectives will be accomplished by extensive review of scientific progress at monthly meetings attended by all projects and cores within the program and affiliated lab groups from around the Bay Area; smaller meetings held by subgroups; and shared interviews of potential postdoctoral fellows. Scientific direction and research results will be subject to intensive, constructive criticism by investigators within the P01 and by regular evaluations from an external scientific advisory board. We strongly believe that our extensive collaborative approach promoted by Core A is unique. Indeed, this program represents the nucleating group for Bay Area investigators studying intracellular pathogens and innate immunity. The Specific Aims are: 1) Conduct management of scientific progress; 2) Establish and engage external advisory board to review scientific progress; and 3) Implement financial management and administrative support. To facilitate interactions among investigators, two-hour joint lab meetings will continue to be held monthly at UC Berkeley. These monthly meetings consist of introductory discussions and two scientific presentations from two different labs. Given possible restrictions related to the coronavirus, we will use teleconferencing options for meetings, if necessary. The external scientific advisory board, chaired by Dr. Jeffrey F. Miller from UCLA, will provide rigorous and consistent evaluation of the program’s scientific direction, research results, and progress. Core A will facilitate the relationship between the external board and the investigators as well as among the Project Leaders themselves, who will meet once per month for 2 hours in the Program Director’s office. The Portnoy, Vance, Cox, and Stanley labs each have a weekly lab meeting to review ongoing research in their respective labs. In addition to the monthly meetings of P01 personnel and other Bay Area labs, there are many other opportunities for investigators and trainees to interact, exchange ideas, and speak, including a weekly Division of Immunology & Pathogenesis “Research in Progress” meeting on Mondays at noon with 2 speakers from 2 different labs; a seminar series from the Infectious Diseases & Vaccinology Group on Mondays at 10 am, most speakers being from local labs; and the Microbial Biology Seminar Series, held on Wednesdays at noon, with speakers from the US and across the world. Finally, we have an annual immunology retreat at Asilomar that is held jointly with UCSF. Core A serves as the administrative nucleus for the P01 and has been a critical element to our success.