Molecular Biological Approaches to Endocrinology

项目摘要 我们很高兴地报告，我们的培训计划已经成功地培训了具有 成为基因调控领域的下一代富有创造力的独立研究者， 激素和信号作用的机制，发育的分子遗传学，动态平衡，代谢和 疾病、炎症、学习和神经元功能、全球基因组学和当代生物信息学。 这一成就反映了我们培训计划的力量，它的创新、前瞻性思维和 杰出的核心教员，他们反映了La Jolla Mesa地区丰富的研究环境，包括 加州大学圣迭戈分校医学院、生物学院、雅各布斯工程学院和加州大学圣迭戈分校项目 生物信息学和系统生物学。值得注意的是，它还包括索尔克生物研究所， 斯克里普斯研究所和桑福德·伯纳姆普雷比医学发现研究所。此外， 最近成立的加州大学圣地亚哥分校基因组医学研究所进一步加强了对 全球基因组学和染色质生物学的当代领域。核心教员都在国际上。 他们的研究成就得到认可，并在培养研究生方面有很好的记录 从事了非常富有成效的学术和行业职业。我们的项目是高度跨学科的 来自不同学校和项目以及索尔克研究所和斯克里普斯研究中心的教职员工 研究所。研究生沉浸在当代研究方法中，研究重要问题和 在当代全球基因组学技术、生物化学、分子生物学、 遗传学和基因调控。最重要的是，学生应该获得广泛的背景知识 科学文献和批判性思维，以及在这些研究中取得成功的创新精神 区域。正规的课程、实践经验以及密集的互动和协作 项目教员的机会也将为学员追求独立的学术生涯做好准备 这些学科。我们希望有机会继续这一非常成功的博士前研究。 培训补助金，并要求扩大两名博士后实习生的人数。每年6名博士前实习生 都是从竞争激烈的博士项目中挑选出来的。候选人是从1000多名候选人中挑选出来的 申请者。已建立的标准包括研究背景、平均绩点、GRE分数和 与教职员工和高级研究生的访谈。所有项目都有完整的多样性补充 首创精神。学员的目标是从事当代基因调控、内分泌学、 表观基因组学、信息学、染色质生物学、新陈代谢和神经生物学，展望 人类疾病的翻译应用。鼓励学员发展板凳科学方面的技能， 批判性思维、天赋、教学和翻译研究，以求独立 在领先的学术机构担任研究人员，并为生物医学科学做出重要贡献。

Project Abstract We are pleased to report that our Training Program has successfully trained graduate students who have become the next generation of creative independent investigators in the fields of gene regulation, mechanism of hormone and signal action, molecular genetics of development, homeostasis, metabolism and disease, inflammation, learning and neuronal function, global genomics and contemporary bioinformatics. This achievement reflects the strength of our training program fueled by its innovative, forward-thinking, and distinguished core faculty, who reflect the rich research environment of the La Jolla Mesa area that includes the UCSD School of Medicine, School of Biology, the Jacobs School of Engineering and the UCSD Program in Bioinformatics and Systems Biology. Notably, it also includes the Salk Institute for Biological Studies, The Scripps Research Institute, and the Sanford Burnham Prebys Medical Discovery Institute. Additionally, the recently constituted UCSD Institute for Genomic Medicine has further strengthened training in the contemporary fields of global genomics and chromatin biology. The core faculty are all internationally recognized for their research accomplishments and have strong records of training graduate students who have gone on to very productive academic and industry careers. Our program is highly interdisciplinary involving faculty from various Schools and Programs as well as the Salk Institute and The Scripps Research Institute. Graduate students are immersed in contemporary research approaches to important questions and have the full range of training in contemporary global genomics techniques, biochemistry, molecular biology, genetics, and gene regulation. Most importantly, students are expected to acquire a broad background of the scientific literature, and critical thinking, as well as the creative spirit that underlies success in these research areas. Formal coursework, hands-on bench experience, and intensive interaction and collaboration opportunities with program faculty will also prepare trainees for pursuing independent academic careers in these disciplines. We hope to be permitted the opportunity to continue this highly successful predoctoral training grant with a request for expansion for two postdoctoral trainees. Six predoctoral trainees per year are drawn from the highly competitive PhD programs. Candidates are chosen from more than 1000 applicants. Established criteria include research background, grade point average, GRE scores, and interviews with faculty and senior graduate students. All programs have a full complement of Diversity Initiatives. Trainees are directed towards careers in contemporary gene regulation, endocrinology, epigenomics, informatics, chromatin biology, metabolism and neurobiology, with a perspective towards translational application to human disease. Trainees are encouraged to develop skills in bench science, critical thinking, grantsmanship, teaching, and translational research in order to become independent investigators at leading academic institutions and make important contributions to biomedical science.