Pelvic Floor Disorders Network 2015

盆底疾病网络周期IV -行政补充- UT西南 项目总结/摘要 我们的主要目标仍然是积极参与骨盆底疾病网络（PFDN）， 有效的患者招募、参与和保留种族和民族多样化的患者人群， 所有检查女性骨盆底疾病（PFDs）的研究。我们的第二个目标是将创新研究 向该网络提出建议，重点是探索病理生理学和预防的转化目标 明确定义的临床研究人群中的PFDs。为了实现这些目标，我们描述了资格和 女性盆腔医学和重建外科（FPMRS）教师和研究团队的经验， 得克萨斯大学西南医学中心和帕克兰医院，设施和病人人数 可用于执行临床方案，以及我们最先进的科学方法来研究PFDs。的 本申请中描述的临床研究团队积极参与了PFDN的周期II和IV， 在每项PFDN临床试验中实现了稳健的招募和保留。我们的临床和研究诊所服务于 医疗贫困患者（帕克兰医院）和私人保险患者（大学实践）。这些 诊所提供了多样化的患者人群，这使我们成为拉丁美洲妇女的主要招聘者。 PFDN（周期II）。我们一直积极参与PFDN的所有其他方面，包括概念提案，委员会 参与和手稿准备。我们的研究中心/团队的独特之处在于PFDN的生物储存库， 它一直住在UT西南在周期II-IV，并已成为不可或缺的其他翻译 研究的努力。此外，我们妇产科的科学资源和基础设施是 中心重点是基因组学、表观遗传学和基因调控在妇女健康各个方面的作用。 UT西南大学的FPMRS医生仍然致力于严格的对照试验，旨在客观地 评估与PFDN的使命一致的非手术和手术治疗原则。随着成长， 多样化的临床患者群体，一个致力于和经验丰富的研究团队，具有成功的血统， 内部和外部合作，以及支持额外翻译PFD的资源和专业知识 研究，UT西南准备和充满活力，继续通过“桥梁年”的所有PFDN活动 第四周期后。

Pelvic Floor Disorders Network Cycle IV – Administrative Supplement – UT Southwestern PROJECT SUMMARY / ABSTRACT Our primary goal remains to actively engage in the Pelvic Floor Disorders Network (PFDN) through efficient patient recruitment, participation, and retention of a racially and ethnically diverse patient population in all studies examining pelvic floor disorders (PFDs) in women. Our second goal is to bring innovative research proposals to this Network with emphasis on translational aims that explore the pathophysiology and prevention of PFDs in well-defined clinical study populations. To accomplish these aims, we describe the qualifications and experience of the Female Pelvic Medicine and Reconstructive Surgery (FPMRS) faculty and research teams at the University of Texas Southwestern Medical Center and Parkland Hospital, the facilities and patient population available to carry out clinical protocols, and our state-of-the-art scientific approaches to the study of PFDs. The clinical research team described in this application actively participated in Cycles II and IV of the PFDN and achieved robust recruitment and retention for each PFDN clinical trial. Our clinical and research clinics serve both medically indigent patients (Parkland Hospital) and private, insured patients (university practice). These clinics provide a diverse patient population which allowed us to be the leading recruiter of Latina women in the PFDN (Cycle II). We have been active in all other aspects of the PFDN including concept proposal, committee participation, and manuscript preparation. Unique to our research site/ team is the Biorepository for the PFDN, which has remained housed at UT Southwestern in Cycles II-IV and has become integral to other translational research endeavors. Further, the scientific resources and infrastructure within our Ob/Gyn department are centrally focused on the role of genomics, epigenetics and gene regulation in various aspects of women’s health. The FPMRS physicians at UT Southwestern remain dedicated to rigorous controlled trials intended to objectively evaluate principles of non-surgical and surgical care consistent with the mission of the PFDN. With a growing, diverse clinical patient population, a committed and seasoned research team with a pedigree of successful internal and external collaborations, and the resources and expertise to champion additional translational PFD research, UT Southwestern is ready and energized to continue all PFDN activities through the “bridge year” following Cycle IV.