Xenbase - Computation

组成部分：补偿 项目总结/摘要 计算组件的目标是保持Xenbase的可操作性、可靠性和响应性， 维护和升级高峰所需的硬件、基础设施、软件和系统， 提高业绩，并制定和支持其他各节所述的拟议改进措施 这个应用程序。像Xenbase这样的知识库必须集成和处理各种各样的 数据，并为用户提供查询和探索其内容的工具和界面。这些都是 计算过程。此外，Xenbase必须与外部数据库连接， 资源（NCBI，AGR，出版商）同步内容并提供带注释的Xenopus 数据虽然对用户是不可见的，但会发生相当大的计算量 每次研究人员使用Xenbase时，都会在幕后进行演示。Xenbase是一个复杂的计算 由多个独立的数据库、许多不同的软件应用程序 用户和管理员网络界面，以及许多自动化数据交换管道。确保 稳定性和增强的性能，工具集被隔离在各自的虚拟机（VM）上- 我们目前在私有云中运行约20个虚拟机，并不断进行监控、测试、维护和修复 来保证一切顺利进行每次新的软件被实施，我们测试它在隔离 虚拟机，然后优化它并将其与现有系统集成。所有这些活动都包含在 计算组件，是实现我们的整体项目目标至关重要。在这 组件，我们描述了维护当前功能，生成 自定义内容和实现扩展和改进所需的资源， 下一个奖项周期 目标1.升级硬件、服务器和软件堆栈，以增加容量并扩展 功能。 目标2.维护和扩展Xenbase内容的计算。 目标3。管理和监控网络和系统

Component: COMPUTATION PROJECT SUMMARY/ABSTRACT The goal of the Computation component is to keep Xenbase operational, reliable, and responsive, to maintain and upgrade the hardware, infrastructure, software and systems necessary for peak performance and to develop and support the proposed improvements described in other sections of this application. Knowledgebases like Xenbase must integrate and process a diverse array of data and provide users with tools and interfaces to query and explore its content. These are all computational processes. In addition, Xenbase must interface with external databases and resources (NCBI, the AGR, publishers) to synchronize content and to provide annotated Xenopus data. Although invisible to the user, there is a considerable amount of computing that occurs behind the scenes every time a researcher uses Xenbase. Xenbase is a complex computing environment consisting of multiple, separate databases, many different software applications, user and curator web interfaces, and many automated data exchange pipelines. To ensure stability and enhance performance, tool sets are isolated on their own virtual machines (VMs) - we currently run ~20 VMs in our private cloud - and we constantly monitor, test, maintain, and fix bugs to keep it all running smoothly. Each time new software is implemented, we test it on isolated VMs, then optimize and integrate it with existing systems. All of this activity is contained within the Computation component and is paramount to achieving our overall project goals. In this component, we describe the computing work needed to maintain current functionality, generate custom content and the resources necessary to implement expansions and improvements over the next award cycle. Aim 1. Upgrade hardware, servers and software stack to increase capacity and expanded functionalities. Aim 2. Maintain and expand computation of Xenbase content. Aim 3. Manage and monitor networking and systems