Brain Plasticity and Clinical Consequences of Adult-Onset Asymmetric Hearing Loss

项目总结 永久性感音神经性不对称听力损失(AHL)干扰双耳耳间信息提取 正在处理。使用至少15分贝的耳间差异作为AHL的定义，患病率估计各不相同 范围广泛，从1%到50%。在有职业噪声暴露的队列中，AHL的患病率从15%- 49%。严重的临床后果包括在嘈杂环境中难以识别声音目标和 空间听力下降。除了这些损害之外，AHL中可帮助的较差的耳朵还面临着 加速衰弱，经常受耳鸣的影响。我们对这一关系的理解有很大的差距 中枢神经系统沿AHL幅度连续体的变化，听力学和 心理声学结果和耳鸣感觉。弥合这一知识差距将是 先进的诊断工具，启发AHL的创新治疗。由锚定的神经成像和 听力正常和单侧耳聋是AHL最极端的形式，我们建议 缩小这一知识鸿沟。 对急性淋巴细胞性耳聋临床后果的综合研究应考虑不良反应下的听力表现 条件、空间听力和耳鸣结果，以及它们的中枢神经相关性。我们提出了一个纵向的 急性淋巴细胞性白血病患者治疗前后神经影像特点及临床评价研究 放大。我们将使用静息状态脑磁图成像(RS-MEGI)和功能磁学 磁共振成像(RS-fMRI)、基于任务的MEGI和弥散磁共振成像，以检查时间、功能和 结构特征，以及评估听力表现和耳鸣的听力学和心理声学测试 结果。这项观察性研究将收集参与者的数据，这些参与者将接受常规的放大治疗 根据需要，为AHL提供个性化的耳鸣声音治疗。我们将评估重测信度 神经成像特征，并评估神经成像特征、听力表现和耳鸣结果 治疗前及治疗后3、6、12个月。本研究的具体目的是考察：1) AHL的临床结果：2)使用MEGI的AHL听觉半球间组织，以及3)AHL整体 使用静息状态MEGI和功能磁共振成像(功能)的脑功能和结构神经成像特征，基于任务 MEGI(功能性)和弥散磁共振(结构性)。

PROJECT SUMMARY Permanent sensorineural asymmetric hearing loss (AHL) disrupts extraction of interaural information for binaural processing. Using a cutoff of at least 15 dB interaural difference as definition of AHL, prevalence estimates vary widely, from 1% to 50%. Among cohorts with occupational noise exposure, AHL prevalence ranges from 15%- 49%. Critical clinical consequences include difficulty with sound target identification in noisy environments and degradation of spatial hearing. Beyond those impairments, the aidable poorer ear in AHL is at risk for accelerated decline and often burdened by tinnitus. There is a wide gap in our understanding of the relationship between central nervous system changes along the continuum of AHL magnitudes, audiological and psychoacoustical outcomes, and tinnitus perception. Closing this knowledge gap would be the first step to advance diagnostic tools and inspire innovative treatments for AHL. Informed by anchoring neuroimaging and audiological data from normal hearing and single-sided deafness, the most extreme form of AHL, we propose to close this knowledge gap. A comprehensive study on the clinical consequences of AHL should address hearing performance under adverse conditions, spatial hearing, and tinnitus outcomes, and their central neural correlates. We propose a longitudinal within-subject neuroimaging features and clinical assessments study of AHL before and after treatment by amplification. We will use resting-state magnetoencephalographic imaging (RS-MEGI) and functional magnetic resonance imaging (RS-fMRI), task-based MEGI, and diffusion MRI to examine temporal, functional and structural features, and audiological and psychoacoustical tests to evaluate hearing performance and tinnitus outcomes. This observational study will collect data from participants who will be treated by routine amplification with individualized tinnitus sound therapies, as required, for AHL. We will evaluate test-retest reliability of neuroimaging features, and assess neuroimaging features, hearing performance, and tinnitus outcomes at baseline and at months 3, 6 and 12 following treatment. The specific aims of this research are to examine: 1) AHL clinical outcomes, 2) AHL auditory interhemispheric temporal organization using MEGI, and 3) AHL whole brain functional and structural neuroimaging features using resting-state MEGI and fMRI (functional), task-based MEGI (functional), and diffusion MRI (structural).