Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's Disease
Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's Disease
批准号:
10410126
负责人:
Brian C. Kraemer
金额:
$76.58万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-05-01 至 2027-04-30
中文摘要
我们正在申请更新华盛顿大学阿尔茨海默病培训计划(ADTP),
“阿尔茨海默病的神经行为、神经病理学和危险因素。”我们的计划侧重于
阿尔茨海默病(AD)和相关痴呆症的转化研究。我们研究培训的目的
该计划是为基础科学,临床和翻译研究人员提供跨学科培训,
他们将能够推进关于病因学、病理生理学和
AD和相关疾病的治疗。我们的培训项目仍然是大学唯一的正式项目
华盛顿大学(UW)的研究中心专注于培训研究人员进行基本的机械,临床和翻译
AD和相关神经退行性痴呆症的研究。
我们的计划是由华盛顿大学和退伍军人事务部的丰富和互动的研究环境的支持
普吉特海湾医疗保健系统,其中一个临界质量的教师进行研究,在整个频谱的AD
以及相关的痴呆症该方案要求提供资金,以维持目前供资的职位,
博士后研究生和4名博士生。博士后博士候选人来自广泛的
学科,包括临床心理学,神经心理学,生物化学,遗传学,神经生物学,
药理学基础科学学员通常在研究生培训的第一年加入该计划
并保持三年。即将到来的MD博士后候选人预计已完成住院医师,
通常在精神病学、神经病学、神经病理学、放射学、核医学、内科或老年医学中
药医学博士和临床博士研究员预计将继续为期两年,并将强烈
鼓励他们留在第三年。博士前学员将从以下UW博士课程招募:
医学科学家培训计划,基因组科学,疾病的分子基础,分子和细胞
生物学,神经科学和药理学课程;招募的博士前学员将加入ADTP计划
在研究生培训的第二年或第三年。直接征聘努力包括服务不足的人员
少数民族学员。
英文摘要
We are applying to renew the University of Washington Alzheimer's Disease Training Program (ADTP),
“Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's Disease.” Our program focuses on
translational research in Alzheimer's disease (AD) and related dementias. The objective of our research training
program is to provide interdisciplinary training for basic science, clinical, and translational researchers so that
they will be able to advance both clinical and mechanistic hypotheses about the etiology, pathophysiology, and
treatment of AD and related disorders. Our training program remains the only formal program at the University
of Washington (UW) focused on training investigators to carry out basic mechanistic, clinical, and translational
research in AD and related neurodegenerative dementing disorders.
Our program is supported by the rich and interactive research environment of the UW and Veterans Affairs
Puget Sound Health Care System, where a critical mass of faculty conduct research across the spectrum of AD
and related dementias. The program requests funding to maintain the currently funded positions for 7
postdoctoral trainees and 4 predoctoral students. Postdoctoral PhD candidates come from a broad range of
disciplines, including clinical psychology, neuropsychology, biochemistry, genetics, neurobiology, and
pharmacology. Basic science trainees typically join the program during their first year of postgraduate training
and remain for three years. Incoming MD postdoctoral candidates are expected to have completed a residency,
usually in psychiatry, neurology, neuropathology, radiology, nuclear medicine, internal medicine, or geriatric
medicine. MD and clinician PhD fellows are expected to remain for a two-year period and will be strongly
encouraged to remain for a third year. Predoctoral trainees will be recruited from the following UW PhD programs:
The Medical Scientist Training Program, Genome Sciences, Molecular Basis of Disease, Molecular and Cellular
Biology, Neuroscience, and Pharmacology programs; recruited predoctoral trainees will join the ADTP program
in their second or third year of graduate training. Direct recruitment efforts are made to include underserved
minority trainees.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SPOP drives neurodegenerative tauopathy
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批准号:10734807
-
项目类别:
-
资助金额:$182.34万
-
财政年份:2023
-
负责人:Brian C. Kraemer
-
依托单位:
Targeting MSUT2 with small molecules to ameliorate pathological tau
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批准号:10735826
-
项目类别:
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资助金额:$218.13万
-
财政年份:2023
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负责人:Brian C. Kraemer
-
依托单位:
Formation of Tau RNA Complexes disrupts tau function and drives tau neuropathology
-
批准号:10777174
-
项目类别:
-
资助金额:$63.88万
-
财政年份:2023
-
负责人:Brian C. Kraemer
-
依托单位:
Developing MSUT2 Nanobodies for Targeting Pathological Tau in Alzheimer's Disease
-
批准号:10518408
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2022
-
负责人:Brian C. Kraemer
-
依托单位:
Developing MSUT2 Nanobodies for Targeting Pathological Tau in Alzheimer's Disease
-
批准号:10363866
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2022
-
负责人:Brian C. Kraemer
-
依托单位:
Reversal of Tau Pathology with MSUT2 siRNA Conjugates
-
批准号:10240452
-
项目类别:
-
资助金额:$9.99万
-
财政年份:2020
-
负责人:Brian C. Kraemer
-
依托单位:
Reversal of Tau Pathology with MSUT2 siRNA Conjugates
-
批准号:9909831
-
项目类别:
-
资助金额:$21.3万
-
财政年份:2020
-
负责人:Brian C. Kraemer
-
依托单位:
Protection from pathological tau by activation of the ER unfolded protein response
-
批准号:10347310
-
项目类别:
-
资助金额:$52.0万
-
财政年份:2020
-
负责人:Brian C. Kraemer
-
依托单位:
Protection from pathological tau by activation of the ER unfolded protein response
-
批准号:10551219
-
项目类别:
-
资助金额:$52.0万
-
财政年份:2020
-
负责人:Brian C. Kraemer
-
依托单位:
Protection from pathological tau by activation of the ER unfolded protein response
-
批准号:9901055
-
项目类别:
-
资助金额:$53.0万
-
财政年份:2020
-
负责人:Brian C. Kraemer
-
依托单位:
Inhibiting pathological TDP-43 phosphorylation as a therapeutic strategy for ALS
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批准号:9348132
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2017
-
负责人:Brian C. Kraemer
-
依托单位:
Inhibiting pathological TDP-43 phosphorylation as a therapeutic strategy for ALS
-
批准号:9898277
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2017
-
负责人:Brian C. Kraemer
-
依托单位:
MSUT2 modulates pathological tau in AD and model organisms
-
批准号:9285130
-
项目类别:
-
资助金额:$317.4万
-
财政年份:2017
-
负责人:Brian C. Kraemer
-
依托单位:
Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's Disease
-
批准号:10624460
-
项目类别:
-
资助金额:$78.66万
-
财政年份:2016
-
负责人:Brian C. Kraemer
-
依托单位:
Acquisition of a ProteinSimple capillary electrophoresis protein immunoanalyzer
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批准号:8949379
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2015
-
负责人:Brian C. Kraemer
-
依托单位:
Unfolded protein response activation protects neurons against pathological tau
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批准号:9064862
-
项目类别:
-
资助金额:$17.58万
-
财政年份:2015
-
负责人:Brian C. Kraemer
-
依托单位:
Identifying new tau targeted therapeutics: a drug repurposing approach
-
批准号:9275429
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Brian C. Kraemer
-
依托单位:
Identifying new tau targeted therapeutics: a drug repurposing approach
-
批准号:8994167
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Brian C. Kraemer
-
依托单位:
Identifying new tau targeted therapeutics: a drug repurposing approach
-
批准号:8815851
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项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Brian C. Kraemer
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依托单位:
MSUT2/SUT2 controls tau protein aggregation and neurotoxicity.
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批准号:8198359
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项目类别:
-
资助金额:$0.0万
-
财政年份:2010
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负责人:Brian C. Kraemer
-
依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
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批准号:81000622
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项目类别:青年科学基金项目
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资助金额:20.0万元
-
批准年份:2010
-
负责人:梁胜
-
依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
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批准号:31060293
-
项目类别:地区科学基金项目
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资助金额:26.0万元
-
批准年份:2010
-
负责人:郭亚芬
-
依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究
-
批准号:30960334
-
项目类别:地区科学基金项目
-
资助金额:22.0万元
-
批准年份:2009
-
负责人:董贵成
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依托单位: