04 - Cancer Control and Population Sciences

癌症控制与人口科学(CCPS)计划 概述和目标：阿拉巴马州的癌症负担超过美国，主要是由于贫困和 普遍存在的危险因素(如肥胖、不良饮食、缺乏体育活动、吸烟、HPV疫苗接种率低)，且较高 在农村、非西班牙裔黑人和精选的移民人口中。CCPS计划的目标是高歌猛进 跨癌症连续统一体的影响、范式转换、多学科转换研究，以减少 在我们的集水区和更远的地方，癌症负担。研究要点：初级预防，CCPS 成员们开发并测试了一种与文化相关的干预措施，该干预措施提高了 拉丁裔移民的女儿与阿拉巴马州公共卫生部合作增加HPV 疫苗接种率在一年内从35%上升到50%。在癌症患者和幸存者中，CCPS研究小组测试了 并翻译了促进药物依从性的创新战略，以便在儿童中传播 肿瘤学小组，并在农村和少数民族促进安全减肥以及改善饮食和体力活动 在一个P01项目中与肥胖有关。CCPS成员，姑息治疗专家，发布了一项基于证据的研究，完 向全国45个退伍军人事务医疗中心提供生活干预，并正在调整干预措施，以解决 阿拉巴马州农村和48个国家癌症研究所社区肿瘤学研究计划的照顾者 练习。方案活动：与联合国儿童基金会办公室的双向沟通促进了CCPS的研究 社区推广和参与，癌症研究培训和教育协调办公室，内部和 方案间分组、研讨会、务虚会、内部科学同行审查和非正式陪同 跨学科协作。整体支持由共享资源提供(70%由CCPS使用 成员)和奥尼尔投资计划(从14个试点奖项中获得63.8万美元，利用240万美元的外部资金)。 UAB-Tuskegee-Morehouse医学院的伙伴关系以及与其他大学中心的合作 (例如，营养与肥胖研究中心和跨学科健康差异研究中心) 促进我们针对癌症差异的研究。总体而言，这种支持是奖项不可或缺的一部分 推动我们的项目目标，如1个P01、3个U01和29个协同R01的S。成员：CCP成员包括36个 来自13个系和5个学院的教职员工，他们获得了总计820万美元的年度计划同行直接审查 成本(2021年)，包括NCI资金增加22%(510万美元)。CCP成员工作效率高， 协作，如其在当前CCSG周期(2016-2021年)中以癌症为重点的出版物(704)所显示的那样， 其中29%是计划内的，30%是计划间的，77%是机构间的，10%是 A影响因子≥9.0。未来方向：我们为奥尼尔战略计划做出贡献，并在其指导下，以及 设定了基准，以推进和转化癌症预防和检测、肥胖和 癌症，并减轻癌症后的发病率和死亡率。

ABSTRACT – CANCER CONTROL AND POPULATION SCIENCES (CCPS) PROGRAM Overview and Goals: The cancer burden in Alabama exceeds that of the US, largely due to poverty and prevalent risk factors (e.g., obesity, poor diet, physical inactivity, tobacco use, low HPV vaccination) and is higher among rural, Non-Hispanic Black, and select immigrant populations. The CCPS Program goal is to advance high impact, paradigm-shifting, multidisciplinary translational research across the cancer continuum to reduce the cancer burden in our catchment area and beyond. Research Highlights: For primary prevention, CCPS members developed and tested a culturally relevant intervention that increased HPV vaccination rates among daughters of LatinX immigrants and partnered with the Alabama Department of Public Health to increase HPV vaccination rates from 35 to 50 percent in one year. In cancer patients and survivors, CCPS study teams tested and translated innovative strategies to promote medication adherence for dissemination in the Children’s Oncology Group and promoted safe weight loss as well as improved diet and physical activity in rural, minorities with obesity in a P01 project. CCPS members, experts in palliative care, disseminated an evidence based, end of life intervention to 45 Veterans Affairs Medical Centers nationwide, and are adapting interventions to address caregivers in rural Alabama and in 48 National Cancer Institute Community Oncology Research Program practices. Program Activities: CCPS research is catalyzed by bidirectional communication with the Office of Community Outreach and Engagement, Cancer Research Training and Education Coordination office, intra- and inter-programmatic subgroups, seminars, retreats, internal scientific peer-review and informal chaperoning of transdisciplinary collaborations. Integral support is provided by Shared Resources (70% utilized by CCPS members) and the O’Neal Invests Program ($638K from 14 pilot awards leveraged $2.4M in extramural funding). The UAB-Tuskegee-Morehouse School of Medicine partnership and collaborations with other university centers (e.g., Nutrition and Obesity Research Center, and Transdisciplinary Health Disparities Research Center) facilitate our research that targets cancer disparities. Collectively, this support was integral to the awards that drive our program goal, e.g., 1 P01, 3 U01s and 29 collaborative R01’s. Members: CCPS members include 36 faculty from 13 Departments and 5 Schools, who obtained a total of $8.2M annual program peer-reviewed direct costs (2021) including a 22% increase in NCI funding ($5.1M). CCPS members are highly productive and collaborative, as shown by its (704) cancer-focused publications in the current CCSG cycle (2016-2021), of which 29% were intra-programmatic, 30% inter-programmatic, 77% inter-institutional, and 10% in journals with an impact factor ≥ 9.0. Future Directions: We contribute to, and are guided by, the O’Neal Strategic Plan, and have set benchmarks to advance and translate discoveries in cancer prevention and detection, obesity and cancer, and mitigating morbidity and mortality after cancer.