iCare - Integrated assessment and Advanced Characterisation of Neuro-Nanotoxicity

由于人造纳米材料的发明、生产和使用呈指数增长，人造纳米材料偶然、意外或故意释放到环境中以及暴露于人类是不可避免的。它可以对我们的健康产生巨大的影响，特别是在最敏感和暴露的人体器官，如我们的肺，胃和大脑。iCare旨在开发一套弹性和自适应的先进成像技术，以量化复杂基质中ANMC的物理化学性质。主要目标将侧重于一个综合模型系统，以表征和预测纳米材料对大脑健康的影响，以防止纳米材料的毒性。该项目向工业界提供了一套技术和方法，以评估纳米材料在暴露于模拟环境和生物暴露的复杂均质基质时在形态、化学成分和反应性方面的变化，特别强调高分辨率成像方法。为了实现这一目标，该项目汇集了来自不同背景的11个合作伙伴，如来自不同欧盟和非欧盟国家的RTO，中小企业，工业和大学，以及来自纳米技术，毒理学，先进材料，先进成像等不同领域的合作伙伴。该联合体将致力于开展不同的活动，以实现以下成果：1）实现新的高分辨率方法和新的超分辨率成像技术的新成像方法2）开发毒理学测试方案并解决纳米毒理学中的当前差距，3）开发在体外和体内测试中带来差距的工具和方法，4）材料和产品开发的效率5）提供可靠的数据和改进的数据报告，并最终开发可用于监管框架的统一标准化测试方法。

The incidental, accidental, or intentional release of manufactured nanomaterials into the environment and its exposure to humans is inevitable due to the exponential growth in invention, production, and use of them. It can have a huge impact in our health specially in the most sensible and exposed human body organs such us lungs, stomach, and brain. iCare aim to to develop a resilient and adaptive set of advanced imaging technologies to quantify physical-chemistry properties for ANMC in complex matrices. The main objective will focus on a integrated model system to characterize and predict the impact of nanomaterials on brain health to prevent the toxicity nanomaterials. The project makes accessible for industry a set of techniques and methodologies to evaluate changes in morphology, chemical composition and reactivity of nanomaterials when exposed to complex homogenous matrices mimicking environmental and biological exposure, with a particular emphasis on high-resolution imaging methodologies. To achieve this goal the project the project brings together in the consortium 11 partners from different backgrounds such as RTOs, SMEs, industries and universities from different EU and non-eu countries and coming from different fields like nanotech, toxicology, advanced materials, advanced imaging, … During the 48 months long of the project, the consortium will work on the development of different activities to achieve the following results: 1)new imaging methods achieving new high resolution methodologies and new super resolution imaging techniques 2)development of toxicology testing protocols and addressing current gaps in nanotoxicology, 3)development of tools and methods bringing the gap in vitro and in vivo testing, 4)efficiency of materials and product development 5)Delivery of reliable data and improved data reporting and finally development of harmonised standardised test methods that can be used in regulatory frameworks.