Coordinating center for collaborative marmoset research

项目总结/摘要 普通的绒猴（Callithrix jacchus）已经成为一种非常重要和易于驾驭的非人类动物。 灵长类动物（NHP）模型的神经科学研究，适应遗传操作和定向育种。 神经科学界采用绒猴模型存在几个障碍，包括一个小的 美国的人口普查规模（少于2，500只动物），关于资源可用性的沟通不畅， 对研究中绒猴的优势和局限性缺乏了解，缺乏正式的结构 协调与绒猴研究相关的信息和资源共享。 在这项申请中，我们建议建立一个绒猴协调中心（MCC），作为NIH脑的一部分， 通过推进创新神经技术（BRAIN）计划进行的研究将解决这些限制 通过建立我们在NHP信息学和绒猴研究方面的经验。作为MCC的基础，我们 将基于LabKey数据建立一个新的信息学框架， 管理系统.该基础设施将源自多个地点现有的LabKey系统 国家灵长类动物研究中心，并已优化为NHP研究，包括绒猴， 多年的生产。这个信息学系统将以绒猴的基本统计数据作为初始化 参与中心提供的实验室人群，预先记录个人水平的信息， 已经被记录下来，更广泛地提供给神经科学界。人口和遗传 信息将在参与中心之间共享和讨论，以协调绒猴群 管理符合美国动物学协会的实践指南。 管理协委会一旦投入运作，将由两部分组成： 存储在LabKey中的绒猴数据资源，以及有关绒猴生物学的背景内容， 2）由MCC工作人员组成的礼宾人员，并由绒猴科学咨询委员会加强 神经科学专家该网站将提供现有的绒猴神经科学项目的摘要， 允许感兴趣的研究人员搜索动物库存并请求动物。礼宾部将为您提供 回答关于中心和在神经科学中使用绒猴的基本问题。数据和 MCC的人力资源将为绒猴神经科学研究提供一个重要的门户， 合作、服务协议或动物转移。

PROJECT SUMMARY/ABSTRACT The common marmoset (Callithrix jacchus) has emerged as a critically important and tractable non-human primate (NHP) model for neuroscience research accommodating genetic manipulation and directed breeding. Several barriers to the adoption of marmoset models by the neuroscience community exist, including a small census size in the United States (fewer than 2,500 animals), poor communication about resource availability, a poor understanding of the strengths and limitations of marmosets in research, and a lack of a formal structure for coordinating the sharing of information and resources related to marmoset research. In this application, we propose to establish a Marmoset Coordinating Center (MCC) as part of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative that will address these limitations by building upon our experience in NHP informatics and marmoset research. As the foundation for the MCC, we will build a new informatics framework for coordinating marmoset research based on the LabKey data management system. This infrastructure will be derived from the existing LabKey system in place at multiple National Primate Research Centers, and which has been optimized for NHP research, including marmosets, over years of production. This informatics system will be initialized with basic statistics on the marmoset laboratory populations provided by participating centers, making pre-recorded, individual-level information that is already recorded more broadly available to the neuroscience community. Demographic and genetic information will be shared and discussed among participating centers, to coordinate marmoset colony management in line with American Zoological Association practice guidelines. Once operational, the MCC will be comprised of two parts: 1) a web-based portal to provide access to the marmoset data resources stored in LabKey, as well as background content on marmoset biology and neuroscience; 2) a concierge comprised of MCC staff and augmented by a scientific advisory board of marmoset neuroscience experts. The website will provide summaries of existing marmoset neuroscience projects, and allow interested investigators to search animal inventory and request animals. The concierge will be available to answer basic questions about the Center and the use of marmosets in neuroscience. Together, the data and human resources of the MCC will provide an essential portal into marmoset neuroscience research through collaboration, service agreement, or animal transfer.