Functional analysis of SIRPG, a T cell-specific autoimmune gene

项目摘要 最近的遗传学研究已经确定了大量的基因变异，这些变异与更高的风险有关 自身免疫性疾病。例如，SIRPG基因上的几个遗传变异与更高的 患1型糖尿病的风险。SIRPG几乎只在T淋巴细胞中表达。然而，它的生理上 由于缺乏老鼠的同源物，功能仍不清楚。我们也不知道它是如何遗传的 变异导致了1型糖尿病的发病机制。这些重要的问题将在 该项目利用尖端基因工程技术来消融SIRPG或复制其基因 人类T细胞的变异。从这个项目中产生的数据不仅将促进我们对 SIRPG的功能也是1型糖尿病的发病机制，并最终导致新的治疗方法 自身免疫性疾病的治疗方法。

Project Summary Recent genetic studies have identified numerous genetic variations that are associated with higher risk of autoimmune diseases. For example, several genetic variations at the SIRPG gene are associated with higher risk of type 1 diabetes. SIRPG is expressed almost exclusively in T lymphocytes. However, its physiological function is still unknown due to the lack of a mouse homologue. Nor do we understand how its genetic variations contribute to the pathogenesis of type 1 diabetes. These important questions will be addressed in this project with cutting edge genetic engineering technology to ablate SIRPG or reproduce its genetic variations in human T cells. Data generated from this project will advance our understanding of not only the function of SIRPG but also the pathogenesis of type 1 diabetes, and eventually lead to novel therapeutic approaches of autoimmune diseases.