Inorganic functional immunomodulators targeting Th-17 immune response for vaccines and cell therapies

该项目旨在提供一种新型无机材料，可以深刻调节免疫反应。这些产品基于无机材料平台，旨在提高针对感染性疾病和癌症的当前和下一代疫苗和细胞疗法的质量和功效。所探索的功能材料可以通过在合成步骤中应用工程原理精确控制颗粒的理化性质，从而实现针对相应疾病靶标的定制化合物，以引发最佳免疫反应。这些化合物的免疫应答被证明是完全基于功能材料的性质可预测的，从而能够快速计算机筛选最佳候选物，在这个项目中，我们将通过合理设计无机免疫调节剂并筛选它们的免疫反应，将工程原理应用于免疫生物学系统，相关分析。它将专门针对防御许多细菌和真菌病原体所需的特殊类型的免疫力，并且对于大多数这些病原体感染的粘膜部位（例如肺，肠道和生殖道）的防御特别重要。

The project aims to deliver a new class of inorganic materials that profoundly modulate immune responses. These are based on an inorganic material platform to improve the quality and efficacy of current and next generation vaccines and cell therapies targeting infectious diseases and cancers.The functional material explored allows precise control of the physicochemical properties of the particles by applying engineering principles during the synthesis step, enabling tailor-made compounds specifically designed to elicit the optimum immune response for the respective disease targets. The immune response of these compounds proved to be predictable based purely on the properties of the functional materials enabling rapid in-silico screening of best candidates, accelerating development timelines for a broad range of modalities and probability of success in clinical studies.In this project we will apply engineering principles to immunobiological systems by rationally design inorganic immunomodulators and screen them for their immunological response in relevant assays. It will specifically target the special types of immunity needed for defence against many bacterial and fungal pathogens, and which are particularly important for defence at mucosal sites where most of these pathogens infect (e.g. lungs, gut and genital tract).