Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

总结 爱因斯坦内森休克中心的健康跨度核心（HSC）是一个独特的资源， 老年科学家需要复杂的体内代谢表型研究，和专门的手术， 包括异时共生。HSC将继续成为“金标准”检测的资源，以评估 衰老-代谢相互作用以及共生手术和组织的资源。期间的目标 下一个资助期将：1）满足对联体共生持续增长的需求， 代谢研究的要求; 2）采用新建立的功能测定和相关服务， 更全面地评估健康寿命，3）提供以下方面的技术支持和咨询 实施老化研究和各种手术和体内方法的常规培训 由核心执行。 该核心的具体目标是：1）提供专门的体内代谢测量; 2） 建议和协助进行健康跨度评估，并提供老年病理学资源; 3）执行 分析全身能量平衡; 4）提供老年啮齿动物的专门外科手术。5)到 提供成像模式，用于量化啮齿动物脂肪组织分布、肝脏和肌肉 糖原和器官脂质。6)提供异时联体手术服务，不断使 相关的组织和血浆储存库。7)积累和定义健康跨度的标准值 跨菌株，并确定其与其他功能域，脆弱性和衰老的老年病理学的关系。 HSC的活动是：1）通过提供独特和有价值的实验测定服务，这些测定不是很高。 可行的或容易获得的，如专门的代谢测定，手术和老年病理学，2） 资源，通过作为正常老化和异时共生组织的组织库， 3）集中一组不同的实验方法， 通过扩展核心能力，提供功能性检测和服务，以促进全面的健康范围 在一个研究中心进行评估，以及4）通过向研究者提供意见进行咨询和培训， 协助设计或实施他们的研究或需要动手核心技术。 人事：1）主任（霍夫曼）处理所有请求，帮助制定实验计划，建立 确定优先次序，监督数据收集，并与HSC工作人员合作编写最终报告。2)的 主任与咨询委员会的主要人员和成员进行协商，提供知识和/或 技术专长和具体项目的援助，3）HSC配备了两名全职经验丰富的 外科医生、一名高级科学家和一名接受过健康寿命评估培训的技术人员进行了研究。 相关性：HSC具有独特的能力来满足寻求高质量的调查人员的要求 体内代谢、健康寿命测定、外科手术和特殊组织以及老年病理学。

Summary The Health Span Core (HSC) of the Einstein Nathan Shock Center serves as a unique resource for geroscientists in need of sophisticated in vivo metabolic phenotyping studies, and specialized surgeries, including heterochronic parabiosis. The HSC will continue to be a resource for ‘gold standard’ assays to assess the aging-metabolism interplay as well as a resource for parabiotic surgeries and tissues. The goals during the next funding period will be to: 1) accommodate the continuously growing demand for parabiosis as well as steady requests for metabolic studies; 2) employ newly established functional assays and related services to provide a more comprehensive assessment of health span, and 3) provide technical support and consultation regarding implementation of aging studies and training in the various surgical and in vivo methodologies routinely performed by the Core. Specific Aims of this Core are: 1) To make available specialized in vivo measurements of metabolism; 2) To advise and assist in performing health span assessments and provide a geropathology resource; 3) To perform analyses of whole body energy balance; 4) To provide specialized surgical procedures in aging rodents. 5) To make available imaging modalities for quantification of rodent adipose tissue distribution, liver and muscle glycogen, and organ lipids. 6) To provide heterochronic parabiosis surgical services and continue to make available a related tissue and plasma repository. 7) Accumulate and define normative values for health span across strains, and determine their relation to other functional domains, frailty and geropathology in aging. Activities of the HSC are: 1) Service by providing unique and valuable experimental assays that are not highly feasible or readily accessible, such as specialized metabolic assays, surgeries and geropathology, 2) Resources, by serving as a tissue repository for both normal aging and heterochronic parabiosis tissue from mice and rats and experimental protocols made available upon request 3) Centralizing a diverse battery of functional assays and services via expansion of Core capabilities to facilitate comprehensive health span assessments at a single site, and 4) Consultation and training by providing input to investigators either seeking assistance in designing or implementing their study or in need of hands-on in Core technologies. Personnel: 1) The Director (Huffman) handles all requests, helps to formulate an experimental plan, establishes prioritization, provides oversight of data collection, and works with HSC staff to compile a final report. 2) The Director consults with key personnel and members of the advisory committee to provide intellectual and/or technical expertise and assistance on specific projects, 3) The HSC is staffed with two full-time experienced surgeons, a senior staff scientist and technician trained in health span assessment to carry out the studies. Relevance: The HSC uniquely harbors the ability to address requirements of Investigators seeking high quality in vivo metabolism, health span assays, surgeries and specialty tissues, and geropathology.