Neural Imaging Module

项目摘要 目前的视觉研究依赖于各种各样的成像技术和模式，从基于MRI的 对活着的大脑进行成像，到检测神经元示踪剂，再到重建 经过组织化学处理的。然而，广泛的此类活动所需的资源和专业知识 技术往往不在个别实验室的范围之内。神经成像模块的目标是 通过使用尸检和尸检技术为调查人员提供广泛的支持来满足这一需求 以使脑组织可视化。具体地说，神经成像模块(1)支持猴子的死前研究， 例如基于功能磁共振成像和CT扫描的方法来指导生理实验；(2)协助验尸 在啮齿动物和猴子身上的实验，包括对特定神经元标记物的染色，评估后 生理学电极跟踪和新的基于病毒的跟踪技术的测试；以及(3)提供工具和 组织学准备的分析服务，包括连续切片的排列和重建 神经元和投射。为了与这些服务的多样性保持一致，该模块促进了 各种各样基于视觉的调查员项目。在模块总监经验丰富的指导下，Dr。 Richard Born和模块工作人员Vladimir Berezovskii博士，由 神经成像模块将继续在推进哈佛地区的视觉研究方面发挥关键作用。

Project Summary Current vision research relies on a wide variety of imaging techniques and modalities, ranging from MRI-based imaging of the living brain, to detecting a neuronal tracer, to reconstructing neurons that have been histochemically processed. However, the resources and expertise required for the wide range of such techniques can often lie outside the scope of individual laboratories. The Neural Imaging Module aims to address this need by providing extensive support to investigators using both pre- and post-mortem techniques to visualize brain tissue. Specifically, the Neural Imaging Module (1) supports pre-mortem studies in monkeys, such as fMRI and CT scan-based methods for guiding physiological experiments; (2) assists with post-mortem experiments in rodents and monkeys, including staining for specific neuronal markers, assessment of post- physiology electrode tracks, and testing of new viral-based tracing techniques; and (3) provides tools and services for analysis of histological preparations, including alignment of serial sections, and reconstructions of neurons and projections. In keeping with the diverse nature of these services, the Module has contributed to a wide variety of vision-based investigator projects. Under the experienced direction of Module Director, Dr. Richard Born, and Module staff member Dr. Vladimir Berezovskii, the expertise and services provided by the Neural Imaging Module will continue to play a critical role in advancing Harvard-area vision research.