Carolina Center on Alzheimer's Disease and Minority Research (CCADMR)

整体部分 项目摘要/摘要 由于其巨大的人力和经济负担，阿尔茨海默病和相关的痴呆症 (ADRD)已经上升到美国(美国)的前列公共卫生议程。更老的 非裔美国人患ADRD的可能性增加。南卡罗来纳州拥有 美国ADRD年龄调整死亡率最高。更好地理解 社会文化、行为和环境决定因素对以下人群的ADRD结果有影响 东南部的非洲裔美国人社区是迫切需要的。这个 拟议的卡罗莱纳阿尔茨海默病和少数民族研究中心的总体目标 (CCADMR)是增加专注于人口健康的研究队伍的多样性 以及通过支持以下方面的持续基础设施实现的ADRD差异的决定因素 代表不足和少数群体(URM)教职员工专注于少数群体的健康和福祉 长辈们。拟议的AD-RCMAR的具体目标是：(1)增加URM的容量 学者们致力于推动关于社会文化、行为和环境因素的科学研究 影响可持续发展战略的成果，以减少与可持续发展战略有关的差距，重点放在非洲 美国人，以及(2)推动ADRD研究的科学，重点是人口健康和 通过以人口为基础的中等教育开展研究性教育的ADRD差异的决定因素 数据分析、跨学科联合指导团队、完善的招聘战略 AD-RCMAR科学家，以及关于健康差距和少数民族老龄化研究的教育。这个 建议的CCADMR是一项全州范围的合作，在以下方面提供指导和教育 使用基于人群的数据集对URM教师的ADRD差异的决定因素 南卡罗来纳州，在包括南卡罗来纳大学在内的三大研究机构 (UofSC)、南卡罗来纳医科大学(MUSC)和克莱姆森大学(CU)，以及三 历史上的黑人学院和大学(HBCU)，包括艾伦大学，克拉夫林 大学和南卡罗来纳州立大学。跨学科和合作伙伴参与的研究， 首席调查人员(PI)和研究团队拥有专业知识的将是 解决与反兴奋剂有关的差距的有效战略。拟建的中心利用 多位绩效指标在为URM提供老龄化和ADRD方面的广泛领导 科学家及其在认知老化、少数民族健康和ADRD差异方面的研究专长。 PIs和Core Lead是久负盛名的合作学者，拥有大量 指导经验和内容知识，将有助于计划的成功 CCADMR。

OVERALL SECTION PROJECT SUMMARY/ABSTRACT Due to its tremendous human and financial burden, Alzheimer’s disease and related dementias (ADRD) have risen to the forefront of the United States (U.S.) public health agenda. Older African Americans are at an increased likelihood of having ADRD. South Carolina has the highest age-adjusted death rate from ADRD in the U.S. A better understanding of the role that sociocultural, behavioral, and environmental determinants have on ADRD outcomes among African-American communities in the Southeast is critically and immediately needed. The overall goal of the proposed Carolina Center on Alzheimer’s Disease and Minority Research (CCADMR) is to increase the diversity of the research workforce focused on population health and determinants of ADRD disparities through sustained infrastructure that will support underrepresented and minority (URM) faculty focused on the health and well-being of minority elders. The Specific Aims of the proposed AD-RCMAR are to: (1) increase the capacity of URM scholars to advance the science on the sociocultural, behavioral, and environmental factors that influence ADRD outcomes in order to reduce ADRD-related disparities, with a focus on African Americans, and (2) advance the science of ADRD research focused on population health and determinants of ADRD disparities through research education in population-based, secondary data analysis, interdisciplinary co-mentoring teams, well-established strategies for recruitment of AD-RCMAR Scientists, and education on Health Disparities and Minority Aging Research. The proposed CCADMR is a state-wide collaboration, providing mentorship and education on determinants of ADRD disparities using population-based datasets for URM faculty throughout South Carolina, at the three major research institutions, including University of South Carolina (UofSC), Medical University of South Carolina (MUSC), and Clemson University (CU), and three Historically Black Colleges and Universities (HBCUs), including Allen University, Claflin University, and South Carolina State University. Interdisciplinary and partner-engaged research, with which the principal investigators (PIs) and research team have expertise, will be an effective strategy for addressing ADRD-related disparities. The proposed Center leverages the multiple PIs’ extensive leadership in providing critical training in aging and ADRD for URM Scientists and their research expertise in cognitive aging, minority health, and ADRD disparities. The PIs and Core Leads are well-established and collaborative scholars with substantial mentoring experience and content knowledge that will contribute to the success of the proposed CCADMR.