Pilot and Feasibility Program

摘要 试点/可行性(P/F)计划是哥伦比亚大学消化和 肝病研究中心(CU-DLDRC)。它的主要目标将是促进高度创新 研究和扩大与消化系统疾病相关的研究机会给新的研究人员。P/F 该计划建立在哥伦比亚初级PI成功试点资助和职业发展的长期历史基础上 大学医学中心(CUIMC)。我们在2019年成功地建立了这个项目，并已资助了七个 到目前为止，调查人员在获得NIH或同等资金方面的成功率很高，提供了 A&gt；25倍的回报率。P/F由两位在成人和儿科消化方面具有杰出专长的主管领导。 卡拉·马戈利斯博士和乌特帕尔·帕杰瓦尼博士负责疾病研究和管理。P/F计划将提供 每年提供三笔25000美元的赠款，其中两笔来自CU-DLDRCC基金，另一笔来自机构支助，这将 使符合条件的调查人员能够探索与CU-DLDRCC两个中心主题之一有关的假设， 为了收集足够的数据来制定研究计划和批准同行审查的申请 校外资金。P/F奖按优先顺序为不同的轨道提供资金。轨道1：寻找新的调查人员 最初的支持。途径2：新的或老牌的调查人员致力于追求创新的高风险、高回报 消化系统疾病方面的项目。途径3：来自其他领域的老牌调查人员寻求应用他们的 消化系统疾病研究方面的专业知识。P/F计划将与其他翻译计划高度协同 和以临床为重点的CUIMC内部筹资机制。P/F获奖者将享受额外的 将大大促进他们的研究的好处，包括远远超出 资助期限；通过丰富融入我们的全面学术指导计划 项目整合以及CU-DLDRC在研究和教育方面的活动，如临床基础团队， 讲习班和研讨会。P/F计划将通过三个月为哥伦比亚大学-刚果民主共和国的使命做出贡献。 具体目标：征集并严格同行评审申请，从而支持高度创新的研究 以及消化研究的后起之秀(目标1)；通过以下方式最大限度地提高P/F资助的研究人员的成功 科学互动、教育、培训和指导的机会以及CU-DLDRC的核心补贴 (目标2)；并通过长期跟踪获奖者，对P/F方案成果进行有效监督 出版物和赠款(目标3)。我们期待P/F计划能够促进高度多样化的 基础和临床人才，并推动创新的有影响力的科学超越当前消化的地平线 研究。这三个目标将在增加多样性、公平和包容性(DEI)的目标下，通过 与丰富计划、其Dei代表和哥伦比亚大学广泛的Dei资源进行合作。 我们已经取得了初步的成功，利用了CU-DLDRC以及机构合作和资源。

SUMMARY The Pilot/Feasibility (P/F) Program represents a central component of the Columbia University Digestive and Liver Disease Research Center (CU-DLDRC). Its primary objectives will be the promotion of highly innovative research and the expansion of digestive disease-related research opportunities to new investigators. The P/F Program is built on a long history of successful pilot funding and career building of junior PIs within Columbia University Medical Center (CUIMC). We successfully established this program in 2019 and have funded seven investigators thus far, who have enjoyed a high rate of success in obtaining NIH or equivalent funding, providing a >25-fold rate of return. The P/F is led by two directors with outstanding expertise in adult and pediatric digestive disease research and administration, Drs. Kara Margolis and Dr. Utpal Pajvani. The P/F Program will provide three grants of $25k each year, two from CU-DLDRCC funds and another from institutional support, that will enable eligible investigators to explore hypotheses related to one of the two central themes of the CU-DLDRCC, in order to gather sufficient data to develop research programs and grant applications for peer-reviewed extramural funding. The P/F awards fund different tracks, in prioritized order. Track 1: New investigators seeking initial support. Track 2: New or established investigators aiming to pursue innovative high-risk, high-reward projects in digestive disease. Track 3: Established investigators from other fields who seek to apply their expertise to research in digestive disease. The P/F Program will be highly synergistic with other translationally and clinically focused intramural internal funding mechanisms at CUIMC. P/F awardees will enjoy additional benefits that will substantially promote their research, including Biomedical Core subsidies that go far beyond the funding duration; integration into our comprehensive academic mentorship program via the Enrichment Program integration as well as into CU-DLDRC activities in research and education such as clinical-basic teams, workshops and seminars. The P/F program will contribute to the mission of the CU-DLRDC through three Specific Aims: To solicit and rigorously peer review applications, thereby supporting highly innovative research as well as rising stars in digestive research (Aim 1); to maximize the success of P/F-funded researchers through opportunities for scientific interactions, education, training and mentorship as well as CU-DLDRC core subsidies (Aim 2); and to provide efficient oversight of P/F program outcomes through long-term tracking of awardees publications and grants (Aim 3). We anticipate the P/F program to enhance the development of the highly diverse basic and clinical talent and to promote innovative impactful science beyond the horizon of current digestive research. These three Aims will be under the goal of increasing Diversity, Equity and Inclusion (DEI), through collaboration with the Enrichment Program, its DEI delegate and the wide range of DEI resources at Columbia. We have achieved initial success already, leveraging CU-DLDRC and institutional collaborations and resources.