West Virginia University Stroke COBRE

项目总结 包括中风在内的神经疾病非常普遍，在医疗、经济和人类方面都有很大的影响。 成本，包括对生活质量产生负面影响的行为/功能中断。因此，纳入 脑部疾病研究中的功能评估是高调、翻译性、 和有影响力的生物医学研究项目。就这样，西弗吉尼亚大学(WVU)的啮齿动物行为 核心(RBC)，一个共享的仪器设施，致力于评估啮齿动物的功能结果，是 西弗吉尼亚大学卒中生物医学研究卓越中心(WVU Stroke Cobre)的重要组成部分。WVU 加拿大皇家银行员工提供从设计到传播的全面行为测试服务，包括： 实验设计和任务选择咨询，写作辅导，行为测试培训，开展 行为测试，维护RBC设备、硬件和软件，以及数据录入和统计分析 援助。到目前为止，RBC提供了27种不同的中风相关测试，包括5个大脑功能领域 使该设施和工作人员能够支持西弗吉尼亚大学调查人员和实习生的工作。这一支持具有 提交了58份内部和外部赠款提案，其中提出了行为分析 (其中18个已获得资金)。此外，还发表了26篇利用RBC服务的期刊文章。为 西弗吉尼亚大学卒中科布雷第二阶段，RBC将1)继续提供高质量的资源和运营 支持西弗吉尼亚大学Stroke Cobre初级调查人员，2)实施新的功能、设施和操作 将程序转变为生产核心以支持行为评估，以及3)使RBC朝着财政方向发展 从西弗吉尼亚州立大学中风科布雷独立出来。充分利用西弗吉尼亚大学RBC的成功实施 在最初阶段，实现这些具体目标将增强我们提供所有必要设备的能力， 进行啮齿动物行为评估以支持西弗吉尼亚大学中风科布雷资助的资源和专业知识 项目以及西弗吉尼亚大学的其他调查人员。这将使加拿大皇家银行成为首屈一指的 评估啮齿动物行为，稳妥地成为中风和中风评估方面的卓越中心 它的共生性，并支持翻译和协作研究，以增强我们对 神经紊乱和阐明治疗中风和其他疾病的可能的治疗干预措施 脑部疾病。

PROJECT SUMMARY Neurological disorders including stroke are highly prevalent and have substantial medical, financial, and human costs, including behavioral/functional disruptions that negatively impact quality of life. As such, the inclusion of functional assessments in studies of brain disorders is a necessary component of a high-profile, translational, and impactful biomedical research program. In this way, the West Virginia University (WVU) Rodent Behavior Core (RBC), a shared instrumentation facility dedicated to the assessment of functional outcomes in rodents, is a vital component of the WVU Stroke Center for Biomedical Research Excellence (WVU Stroke CoBRE). WVU RBC staff offer comprehensive behavioral testing services from ‘design to dissemination’ that include: consultation on experimental design and task selection, writing assistance, behavior testing training, conducting behavioral tests, maintaining RBC equipment, hardware and software, and data entry and statistical analysis assistance. To date, the RBC offers 27 distinct stroke-relevant tests comprising 5 domains of brain function that have enabled the facility and staff to support the work of 64 WVU investigators and trainees. This support has resulted in the submission of 58 internal and external grant proposals in which behavioral assays were proposed (18 of which have been funded). As well, 26 journal articles that utilized RBC services have been published. For Phase II of the WVU Stroke CoBRE, the RBC will 1) continue to provide high quality resources and operational support to the WVU Stroke CoBRE Junior Investigators, 2) implement new capabilities, facilities, and operation procedures to a productive core to support behavioral assessments, and 3) progress the RBC towards fiscal independence from the WVU Stroke CoBRE. Capitalizing on the successful implementation of the WVU RBC during the initial period, achieving these specific aims will enhance our ability to provide all necessary equipment, resources, and expertise to conduct rodent behavioral assessments to support WVU Stroke CoBRE-funded projects as well as other WVU investigators. This will enable the RBC to become a premiere facility for the assessment of rodent behavior, poise WVU to emerge as a center for excellence in the evaluation of stroke and its comorbidities, and support translational and collaborative research to enhance our understanding of neurological disorders and elucidating possible therapeutic interventions for the treatment of stroke and other brain disease.