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West Virginia University Stroke COBRE

西弗吉尼亚大学中风 COBRE

基本信息

批准号：
10640968
负责人：
Elizabeth Engler-Chiurazzi
金额：
$ 30.04万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-08 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640968
关键词：
Advisory Committees Amendment Applications Grants Area Articulation Automation Award Behavior Behavior assessment Behavioral Behavioral Assay Biomedical Research Brain Brain Diseases Centers of Research Excellence Charge Communities Computer software Consultations Core Facility Data Data Collection Dedications Educational workshop Equipment Evaluation Experimental Designs Faculty Fees Funding Growth Human Institution Instruction Investments Measures Medical Methods Mission Persons Phase Pre-Clinical Model Procedures Productivity Publications Publishing Quality Control Quality of life Recommendation Reproducibility Research Research Infrastructure Research Personnel Resources Rodent Role Schedule Services Shoulder Statistical Data Interpretation Stroke Testing Therapeutic Intervention Training Universities Wages West Virginia Work Writing behavior test comorbidity cost design faculty support functional outcomes improved instrumentation journal article nervous system disorder novel therapeutic intervention operation post stroke pre-clinical assessment programs recruit stroke therapy testing services tool university student

项目摘要

PROJECT SUMMARY Neurological disorders including stroke are highly prevalent and have substantial medical, financial, and human costs, including behavioral/functional disruptions that negatively impact quality of life. As such, the inclusion of functional assessments in studies of brain disorders is a necessary component of a high-profile, translational, and impactful biomedical research program. In this way, the West Virginia University (WVU) Rodent Behavior Core (RBC), a shared instrumentation facility dedicated to the assessment of functional outcomes in rodents, is a vital component of the WVU Stroke Center for Biomedical Research Excellence (WVU Stroke CoBRE). WVU RBC staff offer comprehensive behavioral testing services from ‘design to dissemination’ that include: consultation on experimental design and task selection, writing assistance, behavior testing training, conducting behavioral tests, maintaining RBC equipment, hardware and software, and data entry and statistical analysis assistance. To date, the RBC offers 27 distinct stroke-relevant tests comprising 5 domains of brain function that have enabled the facility and staff to support the work of 64 WVU investigators and trainees. This support has resulted in the submission of 58 internal and external grant proposals in which behavioral assays were proposed (18 of which have been funded). As well, 26 journal articles that utilized RBC services have been published. For Phase II of the WVU Stroke CoBRE, the RBC will 1) continue to provide high quality resources and operational support to the WVU Stroke CoBRE Junior Investigators, 2) implement new capabilities, facilities, and operation procedures to a productive core to support behavioral assessments, and 3) progress the RBC towards fiscal independence from the WVU Stroke CoBRE. Capitalizing on the successful implementation of the WVU RBC during the initial period, achieving these specific aims will enhance our ability to provide all necessary equipment, resources, and expertise to conduct rodent behavioral assessments to support WVU Stroke CoBRE-funded projects as well as other WVU investigators. This will enable the RBC to become a premiere facility for the assessment of rodent behavior, poise WVU to emerge as a center for excellence in the evaluation of stroke and its comorbidities, and support translational and collaborative research to enhance our understanding of neurological disorders and elucidating possible therapeutic interventions for the treatment of stroke and other brain disease.

项目概要包括中风在内的神经系统疾病非常普遍，并且对医疗、经济和人力造成重大影响。成本，包括对生活质量产生负面影响的行为/功能中断。因此，纳入脑部疾病研究中的功能评估是引人注目的、转化性、和有影响力的生物医学研究计划。通过这种方式，西弗吉尼亚大学（WVU）啮齿动物行为 Core (RBC) 是一个共享仪器设施，致力于评估啮齿类动物的功能结果西弗吉尼亚大学中风生物医学卓越研究中心 (WVU Stroke CoBRE) 的重要组成部分。西弗吉尼亚大学 RBC 工作人员提供从“设计到传播”的全面行为测试服务，其中包括：实验设计和任务选择咨询、写作协助、行为测试培训、进行行为测试、维护红细胞设备、硬件和软件以及数据输入和统计分析协助。迄今为止，RBC 提供了 27 种不同的中风相关测试，包括 5 个脑功能领域，使该设施和工作人员能够支持 64 名西弗吉尼亚大学调查员和实习生的工作。这种支持有结果提交了 58 份内部和外部拨款提案，其中提出了行为分析（其中 18 个已获得资助）。此外，还发表了 26 篇利用 RBC 服务的期刊文章。为了在 WVU 中风 CoBRE 的第二阶段，RBC 将 1) 继续提供高质量的资源和运营支持西弗吉尼亚大学中风 CoBRE 初级调查员，2) 实施新的能力、设施和操作程序到生产性核心以支持行为评估，以及 3) 推动 RBC 实现财政目标独立于 WVU 卒中 CoBRE。利用 WVU RBC 的成功实施在初期，实现这些具体目标将增强我们提供所有必要设备的能力，进行啮齿动物行为评估以支持西弗吉尼亚大学中风 CoBRE 资助的资源和专业知识项目以及其他西弗吉尼亚大学研究人员。这将使 RBC 成为啮齿动物行为评估，使西弗吉尼亚大学成为评估中风和中风的卓越中心其合并症，并支持转化和合作研究，以增强我们对神经系统疾病并阐明治疗中风和其他疾病的可能治疗干预措施脑部疾病。