U C San Diego Medical Student Summer Aging Research Training

这是加州大学圣地亚哥分校（UC San Diego）与两所邻近机构（Sanford-Burnham-Prebys研究所、Salk研究所）联合提出的一份续约申请，申请对医学学生老龄化研究培训（MSTAR）项目进行为期5年的续约，以响应RFA-AG-20-008。在过去的15年中，我们培训了来自全国各地的239名学生，其中66%来自少数民族，14%来自人民解放运动，59%来自妇女。30%的符合条件的学生在最近的资助期内发表了至少一篇同行评议的文章，74%的学生发表了海报演讲。学员毕业后均在主要项目继续实习；一些人正在从事衰老研究的学术事业，包括阿尔茨海默病和相关痴呆（ADRD）和老年病学。拟议的项目旨在扩大老年领域，特别是ADRD领域的新医师研究人员的渠道。它将在夏季为连续8-12周的研究和临床培训提供全职支持，由教师每年为来自全国各地的18名医学生提供支持。着力招收少数民族、残疾人、弱势群体医科学生。所有实习生将在圣地亚哥度过夏天，在一些最优秀的分子、转化和临床科学家的监督下工作，这些科学家在NIA和其他联邦基金以及医学生的研究培训方面有着出色的记录。我们项目的主要重点将是在与年龄相关的疾病和残疾的背景下，重点关注认知障碍和ADRD的预防、识别和管理。我们的师资力量涵盖了从基础和分子生物学到临床、流行病学和治疗性衰老和年龄相关疾病的研究，特别是ADRD和其他与认知障碍相关的疾病，如心血管疾病、癌症和抑郁症。该项目最重要的方面将是实践研究经验和长期指导关系的发展。此外，教学和临床接触老年病学，特别是ADRD患者的结合，将加强在直接研究经验中学到的技能。这些受训者将于8月初在加州大学圣地亚哥分校的一个研讨会上做口头报告，目标是在一年内在美国老年病学会的年会上提交一份正式的海报，并撰写一份可发表的手稿。一个执行委员会将监督学生的招聘和培训。学员、参与培训的教师和其他利益相关者将对该项目进行严格而广泛的评估，包括长期随访。一个网站将用于促进学员与其导师之间的持续交流。

This is a renewal application from the University of California San Diego (UC San Diego), in conjunction with two neighboring institutions (the Sanford-Burnham-Prebys Institute, the Salk Institute), for a 5-year renewal of the Medical Student Training in Aging Research (MSTAR) program, in response to the RFA-AG-20-008. Over the past 15 years we have trained 239 students from across the country, including 66% from ethnic minority groups, with 14% from URM and 59% women. 30% eligible students from the most recent funding period published at least one peer-reviewed article and 74% students gave a poster presentation. After graduation, all our trainees have continued residency in major programs; several are pursuing academic careers in aging research including Alzheimer’s disease and related dementias (ADRD) and geriatrics. The proposed program is designed to expand the pipeline of new physician investigators in the field of aging, especially ADRD. It will provide full-time support for 8-12 consecutive weeks of research and clinical training during summer, provided by faculty to 18 medical students per year from across the country. We will make special efforts to recruit medical students from underrepresented racial or ethnic minority groups, trainees with disabilities, and those from disadvantaged backgrounds. All trainees will spend the summer in San Diego, working under the supervision of some of the finest molecular, translational, and clinical scientists with outstanding track records of NIA- and other federal funding and of research training of medical students. A primary focus of our program will be on aging well in the context of age-associated disorders and disabilities with a major emphasis on prevention, identification, and management of cognitive impairment and ADRD. Strengths of our faculty range from basic and molecular biology to clinical, epidemiologic, and therapeutic research on aging and age-related disorders, especially ADRD and other diseases associated with cognitive impairment like cardiovascular diseases, cancers, and depression. The most important aspects of this program will be hands-on research experience and development of a long-term mentoring relationship. In addition, a combination of didactics and clinical exposure to geriatrics especially patients with ADRD, will reinforce the skills learned in the direct research experience. The trainees will give an oral presentation at a workshop at UCSD held in early August, with the goal of presenting a formal poster at the annual meeting of the American Geriatrics Society and developing a publishable manuscript within a year. An Executive Committee will oversee the recruitment and training of the students. There will be a rigorous and extensive evaluation of the program by trainees, participating faculty, and other stakeholders including long-term follow-up. A website will be used to facilitate continued communication among the trainees and their mentors.