Core D: Clinical Sciences

项目总结/摘要-临床科学核心D RUSTBELT CFAR临床科学核心D，由经验丰富的 艾滋病毒/艾滋病临床调查人员和工作人员将作为CFAR用户的中央资源， 进行涉及人类参与者、临床数据或样本的临床或转化研究。主 核心系统提供的服务包括：（i）快速获取现有的临床数据和储存库样本， （ii）按需从艾滋病毒感染者、有感染风险的人， 和未感染的低风险个体，以及（iii）CFAR向研究者提供的集中临床支持， 设计、实施、开展和分析临床研究， 锈带CFAR。在下一个赠款周期，我们的能力将大大提高， 杰出的匹兹堡临床队列。合并后的核心将包括艾滋病毒预防、实质性 使用和治疗研究。此外，可以获得的样本范围也将大大增加。 通过采集白细胞去除术样本、胃肠道组织、脑脊液（CSF）， 宫颈组织、胎盘、脐带血、支气管肺泡灌洗液（BAL）、粪便和生殖器分泌物， 翻译研究核心D与患者社区和附属艾滋病组织保持密切关系 通过社区咨询委员会（CAB）的定期会议， 正在进行的倡议，包括无艾滋病匹兹堡和结束流行病在克利夫兰（EtHE在CLE）。锈带 CFAR核心D领导者将指导CFAR研究者并将其与正在进行的队列和研究小组联系起来，例如 匹兹堡HIV肺部研究队列和CFAR综合临床系统网络， 利用这些强大的现有资源。核心D还将与发展核心B密切合作 确保被选定为试点和催化奖的项目取得成功。此外，Core D将与 与核心E（病毒发病机制和持久性）和F（系统生物学和生物统计学）密切合作，以确保 CFAR用户以高效和协调的方式获得全部可用资源， 时尚.最后，核心项目D将与乌干达核心项目C合作， 来自乌干达CFAR国际站点的数据和样本，以及连接国际CFAR调查人员 核心D的可用资源。因此，核心D扩大了对现有资源的利用， 多个机构和从事新的和/或年轻的研究人员在艾滋病毒/艾滋病研究在地方，国家， 和国际水平。

PROJECT SUMMARY/ABSTRACT – CLINICAL SCIENCES CORE D The RUSTBELT CFAR Clinical Sciences Core D, managed by an integrated group of highly experienced HIV/AIDS clinical investigators and staff, will serve as the centralized resource for CFAR users proposing or conducting clinical or translational research involving human participants, clinical data, or samples. The primary services provided by the core are (i) rapid access to existing clinical data and repository samples from persons with HIV (PWH), (ii) on-demand acquisition of fresh biologic samples from PWH, persons at risk for infection, and uninfected low risk individuals, and (iii) centralized clinical support provided by the CFAR to investigators for the design, implementation, conduct, and analysis of clinical research studies across the sites in the expanded RUSTBELT CFAR. In this next grant cycle, our capabilities will be dramatically enhanced by the addition of the outstanding Pittsburgh clinical cohorts. The merged Core will include expertise in HIV prevention, substance use, and cure research. Furthermore, the range of specimens that can be obtained will also be dramatically enhanced through the procurement of leukopheresis samples, gastrointestinal tissue, cerebrospinal fluid (CSF), cervical tissue, placenta, cord blood, bronchoalveolar lavage fluid (BAL), stool, and genital secretions for translational research. Core D maintains strong relationships with patient communities and affiliated AIDS service organizations and agencies through regular meetings of the Community Advisory Boards (CABs) and ongoing initiatives including AIDS-free Pittsburgh and End the Epidemic in Cleveland (EtHE in CLE). RUSTBELT CFAR Core D leaders will guide and link CFAR investigators to ongoing cohorts and study groups such as the Pittsburgh HIV Lung Research Cohort and the CFAR Network of Integrated Clinical Systems to enhance utilization of these powerful existing resources. Core D will also work closely with the Developmental Core B to ensure success of the projects selected for pilot and catalytic awards. Additionally, Core D will collaborate closely with Cores E (Viral Pathogenesis & Persistence) and F (Systems Biology & Biostatistics) to ensure that CFAR users are provided with the full spectrum of available resources in an efficient and coordinated fashion. Finally, Core D will collaborate with the Uganda Core C to provide CFAR users access to participant data and samples from the CFAR international site in Uganda, as well as to link international CFAR investigators to resources available from Core D. Thus, Core D broadens utilization of existing resources with users from multiple institutions and engages new and/or young investigators in HIV/AIDS research at the local, national, and international levels.