Administrative Core

行政核心项目摘要 宾夕法尼亚州ADRC的主要目标是增加阿尔茨海默病（AD）及其相关疾病的研究和教育。 与正常衰老至痴呆连续体中的相关疾病（ADRD）的联系，目的是确定 AD/ADRD的病因和治疗方法。为了实现这一目标，宾夕法尼亚州ADRC协调研究计划， 鼓励新的研究，促进学术研究培训，提供社区教育和外展 并促进新技术的发展，使诊断和治疗个体化，造福于所有人。 老年人及其家庭。行政核心的作用是引导和促进 活动的ADRC核心，并作为一个桥梁ADRC和国家和国际努力 为了实现这些目标。 行政核心将参与一些旨在实现这些目标的不同活动 广泛的目标，包括对ADRC的财政和行政监督（目标1）。ADRC的领导人 由核心领导人和共同领导人组成的ADRC执行委员会将确定优先事项， 实现ADRC的目标。行政核心将选择外部咨询委员会的成员， 该委员会将负责评估中心的进展情况， 建议（目标2）。提供各种论坛和机会，交流意见和传播 数据将通过ADRC赞助的务虚会和系列讲座（目标3）得到行政核心的支持。 这些活动将包括教师和学员的参与，特别是为 后者是为了提供数据和接收反馈。关键的增长和AD/ADRC研究的广度，一个独特的 与年度务虚会主题相关的发展项目计划将促进跨学科工作（目标4）。的 行政核心将支持宾夕法尼亚州ADRC参与许多州，国家和 国际社会努力改善ADRD的护理和治疗，并提供基础设施， 分享数据和生物材料（目标5）。最后，核心将对所有NIA和当地监管机构提供监督。 报告程序和要求（目标6）。 关键的是，行政核心通过协调努力来保持ADRC的“中心性 通过促进与宾夕法尼亚大学其他神经退行性疾病中心的合作， 超越，并通过促进与我们围绕AD异质性的主题相一致的活动。通过实现 为了实现上述目标，我们期望在适当的支持下保持我们的高效率ADRC， 研究，为更大的数据共享工作贡献高度和深度的表型个体， 多样化和多学科的教师，通过培训下一代的调查人员和临床医生，并 教育我们的区域和国家并赋予其权力，以改善大脑健康并实现国家适应行动方案的目标。

Administrative Core Project Summary The primary goal of the Penn ADRC is to increase research and education on Alzheimer’s disease (AD) and its links to related disorders (ADRD) across the continuum of normal aging to dementia with the goal of identifying the causes of and cures for AD/ADRD. To achieve this goal, the Penn ADRC coordinates research programs, stimulates new research, catalyzes academic research training, provides community education and outreach and fosters the development of novel techniques to individualize diagnosis and treatment for the benefit of all elderly persons and their families. It is the role of the Administrative Core to shepherd and facilitate the activities of the ADRC Cores and to serve as a bridge between the ADRC and national and international efforts in pursuit of these goals. Administrative Core will be involved in a number of different activities that are designed to achieve these broad goals, including fiscal and administrative oversight over the ADRC (Aim 1). The leaders of the ADRC and the ADRC Executive Committee, composed of core leaders and co-leaders, will set priorities and develop plans to achieve ADRC goals. The Administrative Core will choose members of an External Advisory Committee that will be charged with the role of evaluating the progress of the Center and providing recommendations (Aim 2). A variety of forums and opportunities for exchange of ideas and dissemination of data will be supported by the Administrative Core through ADRC sponsored retreats and lecture series (Aim 3). These events will include participation of faculty and trainees, providing an opportunity, particularly for the latter, to present data and receive feedback. Critical to the growth and breadth of AD/ADRC research, a unique Developmental Project program linked to topics at annual retreats will foster transdisciplinary work (Aim 4). The Administrative Core will champion participation of the Penn ADRC in numerous state, national, and international efforts to improve care and treatment of ADRD, as well as provide infrastructure to support the sharing of data and biomaterials (Aim 5). Finally, the core will provide oversight on all NIA and local regulatory and reporting procedures and requirements (Aim 6). Critically, the Administrative Core serves to maintain the “centeredness” of the ADRC by coordinating efforts across the individual cores, by promoting collaborations with other neurodegenerative centers at Penn and beyond, and by promoting activities consistent with our thematic focus around AD heterogeneity. By achieving the above aims, we expect to maintain our highly productive ADRC with the appropriate support to do novel research, to contribute highly and deeply phenotyped individuals to larger data sharing efforts, to grow our diverse and multi-disciplinary faculty by training the next generation of investigators and clinicians, and to educate and empower our region and the nation so as to improve brain health and meet the goals of NAPA.