Preconceptional health of Latinas and its association with child adiposity

摘要： 西班牙裔儿童超重/肥胖的患病率高于非西班牙裔儿童。 同行围产期产妇健康状况和生活方式行为被认为是 儿童肥胖的重要危险因素。怀孕前母亲肥胖与更高的 婴儿出生体重和后代肥胖风险增加。母亲的饮食和代谢 在怀孕前的轮廓已被证明对随后的健康产生不利影响， 包括肥胖症的发展。然而，西班牙裔的数据很少 从各种背景和有限的，在一般情况下，由于缺乏标准化 记录孕前健康状况。西班牙裔社区健康研究 拉丁美洲人（HCHS/SOL），来自美国四个州的16，415名成年人（包括3，801名18- 44岁的女性） 城市，是美国最大的西班牙裔/拉丁裔健康研究。基线数据，包括 从2008年至2011年收集了心脏代谢标志物和饮食， 在2014年10月至2017年访视2时收集。因此，HCHS/SOL提供了一个独特的 有机会前瞻性地调查孕前孕产妇健康状况的作用 （心脏代谢生物标志物和饮食）对儿童肥胖症的发展， 了解暴饮暴食的驱动因素，如食物奖励相关行为和心理 妇女的压力作为儿童喂养方法和体重的预测因素。这项辅助研究 计划招募440名母子二人组，即有一个孩子的育龄妇女 (ages 3- 7岁）自基线检查以来出生，以评估儿童的体重、身高和肥胖 （DEXA测量的总脂肪量），饮食和其他生活方式行为，以及女性的食物 与奖励有关的行为。我们建议确定儿童体重的早期可改变的决定因素 和肥胖状态，而不是归因于遗传环境。这是一个新的使用 一个现有的队列来回答非常及时和重要的研究问题， 在这一非常关键的时期， 母亲和孩子的生命周期。

Abstract: Hispanic children have a higher prevalence of overweight/obesity than their non-Hispanic counterparts. Perinatal maternal health status and lifestyle behaviors are recognized as important risk factors for childhood obesity. Pre-pregnancy maternal obesity is linked to higher infant birth weight and increased risk of offspring obesity. The maternal diet and metabolic profile during preconception has been shown to adversely affect the subsequent health of the offspring, including the development of obesity. However, the data are scarce for Hispanics from various backgrounds and limited, in general, due to the lack of standardized documentation of preconception health. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a cohort of 16,415 adults (including 3,801 women 18-44y) from four U.S. cities, is the largest health study of Hispanics/Latinos in the US. Baseline data, including cardiometabolic markers and diet, were collected from 2008 to 2011, and reproductive history is being collected at visit 2 from October 2014 to 2017. Hence, HCHS/SOL offers a unique opportunity to prospectively investigate the role of preconceptional maternal health status (cardiometabolic biomarkers and diet) on the development of childhood obesity and to understand drivers of overeating, such as food reward-related behaviors and psychological stress of women as predictors of child feeding practices and weight. This ancillary study proposes to recruit 440 mother-child dyads; these are women of reproductive age with a child (ages 3-7y) born since the baseline examination to assess child's weight, height and adiposity (total fat mass as measured by DEXA), eating and other lifestyle behaviors, and women's food reward-related behaviors. We propose to identify early modifiable determinants of child's weight and adiposity status that are not attributable to the genetic environment. This is a novel use of an existing cohort to answer very timely and important research questions that have the ability to contribute to the development of intervention studies during this very critical time period in the lifecycle of both the mother and child for the Hispanic population.