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中文摘要
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机遇基金管理核心(OFMC)的广泛目标将是促进早期阶段 支持创新、探索性和研发项目,特别是那些有可能导致 辐射生物剂量学领域的实用产品以及急性和延迟性疾病的预测和预防 受伤。OFMC将支持1)试点项目(基础和翻译研究)和2)高级项目 导致研究新药(IND)的开发项目--使研究和医学成为可能 对策(MCM)发展。 OFMC将为核心的运行生成SOP(标准操作程序),之后 指导委员会的批准,将成为其运作的模板。通信和通信管理处将协调 征求建议书,并协调外部专家小组对建议书的审查 为此目的通过电话会议召开。电信管理委员会将对审查小组在 举行电话会议,并向指导委员会提交排名排序名单,以供作出供资决定。 审查过程中将大力强调创新性和翻译性研究。电信管理公司将 还负责协调财务、IRB和IACUC要求的所有必要文件 与次级受援国机构的合作以及财务监督和报告。电信管理委员会还将协调 年度进度报告,并收集进度报告和续签请求,供指导人员考虑 委员会审议阶段。通讯管理中心亦会协助试验计划获奖者有更多机会发表意见。为 例如,试点获奖者可能有机会为CMCRC年度会议准备海报,以及 将被鼓励在国家会议上发言,例如辐射研究学会年会。 好了!
英文摘要
The broad objective of the Opportunities Fund Management Core (OFMC) will be to facilitate early stage support for innovative, exploratory, and R&D projects, particularly those which have the potential to lead to practical products in the fields of radiation biodosimetry and prediction and prevention of acute and delayed injuries. The OFMC will support 1) Pilot projects (basic and translational research) and 2) Advanced Development projects that lead to Investigational New Drug (IND)-enabling studies and Medical Countermeasure (MCM) development. The OFMC will generate an SOP (Standard Operating Procedure) for the operation of the Core, which after Steering Committee approval, will be the template for its operation. The OFMC will coordinate the process of soliciting proposals, as well as coordinating the review of the proposals by an external panel of experts convened via teleconference for the purpose. The OFMC will tally the scores given by the review panel at the teleconference, and present the rank ordered list to the Steering Committee for funding decisions. Innovative and translational research will be strongly emphasized in the review process. The OFMC will also be responsible for coordinating all necessary documentation of financial, IRB, and IACUC requirements with sub-recipient institutions, as well as financial oversight and reporting. The OFMC will also coordinate annual progress reports, and collect progress reports with renewal requests to be considered by the Steering Committee. The OFMC will also help to facilitate Presentation opportunities for the pilot project recipients. For instance, pilot awardees may be given the opportunity to prepare a poster for the annual CMCRC meeting, and will be encouraged to present at national meetings, such as the Radiation Research Society Annual Meeting. !
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Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
Radiation Biodosimetry Using Gene Expression Signatures
Opportunities Fund Management Core
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