MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) COORDINATING CENTER (CC) - TASK AREA B EXAM 7

动脉粥样硬化的多种族研究(MESA)是一项关于亚临床心血管疾病(CVD)的预测因素和进展的研究，以及亚临床疾病及其进展与临床CVD的关系的研究，以人群为基础的样本，年龄在45-84岁之间，没有临床心血管疾病的证据。6814名自称白人(38%)、非裔美国人(28%)、西班牙裔(22%)或华裔(12%)的参与者是从2000-2002年间从6个美国社区招募的。 受试者通过计算机断层扫描、心脏MRI、颈动脉超声、血流介导的臂动脉扩张、放射状动脉眼压测量、踝臂指数测量和视网膜照相检查亚临床动脉粥样硬化的证据，并进行颈动脉MRI、腹主动脉CT和其他测量。对选定部件的检查在随后的五次检查中重复进行，时间跨度约为16年。在各自的后续检查中，幸存队列的参与率分别为92%、89%、87%、78%和68%。每9-12个月联系一次队列成员，以获取有关生命状态、当前居住地、重大疾病或伤害以及接触者之间住院情况的信息，以确定临床心血管事件。在2020年8月14日结束的最后一次完成的随访中，队列保留率为86%。 自MESA成立以来收集的大量数据和生物样本，以及从MESA参与者那里收集新数据的潜力，为新的科学发现提供了巨大的机会。任务区域2将利用在MESA收集的数据和样本来解决有关临床心血管疾病发展的新问题。将在2021-2023年期间对该队列进行有限的检查。预计将对3000名参与者进行检查。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the predictors and progression of subclinical cardiovascular disease (CVD), and the relationship of subclinical disease and its’ progression with clinical CVD in a population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. 6,814 participants who identified themselves as White (38%), African-American (28%), Hispanic (22%), or Chinese (12%) were recruited from six U.S. communities from 2000-2002. Participants were examined for evidence of subclinical atherosclerosis using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography, and, in subsets, carotid MRI, abdominal aortic CT, and other measures. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years. Participation of the surviving cohort was 92, 89, 87, 78, and 68 percent at each of the respective follow-up examinations. Cohort members have been contacted every 9-12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical CVD events. Cohort retention was 86% at the last completed follow-up ending on August 14, 2020. The wealth of data and biological samples collected since MESA’s inception as well as the potential for new data collection from MESA participants offer vast opportunities for new scientific discoveries. Task Area 2 will leverage data and samples amassed in MESA to address new questions about the development of clinical CVD. A limited examination of the cohort will be conducted during 2021-2023. An estimated 3000 participants will be examined.