Imaging Biomarker Core

项目总结-成像生物标志物岩心 西北ADRC成像生物标记核心公司的长期目标是确定所有符合条件的临床患者的特征 拥有最先进的结构、功能和分子成像的核心参与者，并为以下目的整理这些数据 在未来的项目中使用。西北ADRC临床核心中心目前保持着500多人的队列 参与者。大约一半的临床核心参与者接受了系统的磁共振成像，资金来自 NIA、NINDS和NIDCD的R01。在最后一个周期中，成像生物标记核心增加了成像 覆盖范围从约50%的临床核心队列增加到近70%。在下一个周期，它将获得 并对其他临床核心参与者进行结构、功能和分子成像 其他研究补助金涵盖的对象，以及相关合作研究的对象。我们将使用 先进的采集和分析方法，并确保将这些数据与 支持校内外协作并提供丰富机会的基础设施 训练。成像生物标志器核心与西北ADRC的其他核心高度互连 加强国家适应行动方案和国家行动局使命的方式。它将以以下目标为指导： 1)对缺乏这些的临床核心参与者进行系统和多模式神经成像(MR、PET) 生物标志物以及有资格/招募参加我们支持的合作研究的人。为此，临床核心 参与者包括认知健康的对照组和有遗忘性轻度认知障碍的人 (AMCI)，AD/ADRD患者将使用先进的PET和MR成像方式进行扫描。 2)管理和共享临床核心参与者的综合影像数据集，这将为内部人员提供服务 以及校外合作，包括REC实习生项目。这一目标将利用成熟的制度 用于运行成像数据的质量保证、处理和分析的管道的计算结构。这个 所产生的成像输出将与临床和尸检数据合并在我们统一的ADRC中 与数据管理和统计核心合作开发的NeuroFiles数据库。 成像生物标记核心的基础设施包括两个专门研究的3T西门子磁共振磁体，地址为 西北大学翻译成像中心(CTI)和西北纪念馆的PET/CT扫描仪 医院。数据直接从扫描控制台发送到西北大学神经成像数据 档案馆(Nunda)，其中质量保证和分析工具在高- 名为Quest的性能计算集群。总的来说，这些数据将提高临床和诊断能力 每个临床核心参与者的特征，并将提供给批准的内部和 包括NACC在内的国家合作者。该计划的所有阶段都将为培训提供独特的机会 与成像和翻译研究相关领域的初级调查人员。

PROJECT SUMMARY - IMAGING BIOMARKER CORE The Northwestern ADRC Imaging Biomarker Core has the long-term goal to characterize all eligible Clinical Core participants with state-of-the-art structural, functional, and molecular imaging and curate these data for use in future projects. The Northwestern ADRC Clinical Core currently maintains a cohort of over 500 participants. Approximately half of the Clinical Core Participants receive systematic MR imaging funded by R01s from NIA, NINDS, and NIDCD. During the last cycle, the Imaging Biomarker Core increased imaging coverage from approximately 50% of the Clinical Core cohort to nearly 70%. For the next cycle, it will acquire and process structural, functional, and molecular imaging on additional Clinical Core participants who are not covered by other research grants and who are targeted for relevant collaborative studies. We will use advanced acquisition and analysis methods and ensure these data are integrated with other variables within an infrastructure that supports intramural and extramural collaborations and provides rich opportunities for training. The Imaging Biomarker Core is highly interconnected with the other Northwestern ADRC Cores in a manner that enhances the missions of NAPA and the NIA. It will be guided by the following goals: 1) Acquire systematic and multimodal neuroimaging (MR, PET) on Clinical Core participants who lack these biomarkers and who are eligible/recruited for collaborative studies we support. To this end, Clinical Core participants including cognitively healthy controls, individuals with amnestic mild cognitive impairment (aMCI), and individuals with AD/ADRD will be scanned with advanced PET and MR imaging modalities. 2) Curate and share integrated imaging datasets on Clinical Core participants, which will serve intramural and extramural collaborations including REC trainee projects. This aim will draw upon a mature institutional computing structure to run pipelines for quality assurance, processing, and analysis of imaging data. The resulting imaging outputs will be incorporated with clinical and post-mortem data in our unified ADRC NeuroFiles database developed in collaboration with the Data Management and Statistics Core. The infrastructure of the Imaging Biomarker Core includes two research-dedicated 3T Siemens MR magnets at Northwestern’s Center for Translational Imaging (CTI) and a PET/CT scanner at Northwestern Memorial Hospital. Data are directly routed from the scan console to the Northwestern University Neuroimaging Data Archive (NUNDA), where quality assurance and analysis tools are launched with the support of a high- performance computing cluster called QUEST. Collectively, these data will enhance the clinical and diagnostic characterization of each Clinical Core participant and will be made available to approved intramural and national collaborators including NACC. All phases of this proposal will offer unique opportunities for the training of junior investigators in areas related to imaging and translational research.