Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)

宾夕法尼亚肌肉骨骼疾病中心(PCMD)将继续提供关键资源和 计划并提高研究人员的研究效率，以解决多学科研究 肌肉骨骼问题的策略。该中心的总体目标是促进合作互动 在调查人员中，加快和丰富正在进行的研究的效力和效率，培育新的 合作和新的研究，并最终将我们的研究努力转化为更好的新疗法 肌肉骨骼疾病。中心的主题是“肌肉骨骼的发育、疾病、损伤和修复” 同时解决了3个研究重点领域。我们的PCMD是世界各地肌肉骨骼研究的中心 宾夕法尼亚大学校区和整个地区及邻近各州的肌肉骨骼社区的枢纽。 我们中心的一个重点是在肌肉骨骼组织之间架起主题、方法和范例的桥梁 这一点在研究单个组织时可能会被忽视。由于用于评估机制的方法 一种组织可以帮助其他领域的研究人员，我们的中心将促进这种关键的串扰。为了进一步聚焦， 我们将强调使用独特和复杂的方法跨越长度尺度的小动物模型。 PCMD将提供独特的专业知识和工具来研究这些规模的肌肉骨骼组织。 因此，该中心的主要总体目标仍然是加强和提高 肌肉骨骼发育、疾病、损伤和修复方面的研究人员提供：目标1：创新 跨学科、跨度和层级的领域中的关键资源核心设施。这些核心 设施仍然是uCT成像、生物力学和组织学；目标2：试点和可行性赠款计划， 直接指导；和目标3：教育和研究丰富计划，通过该计划，成员可以 向各国领导人和彼此学习。高质量的肌肉骨骼研究正在由 宾夕法尼亚大学、该地区和邻近各州的许多组织。虽然许多人带来了复杂的方法来 肌肉骨骼问题，很少有人拥有所需的专业知识和设施来执行广泛的严格 在他们自己的实验室里进行专门的分析。中心将提供整合技术的机会，以定义 组织功能、损伤、发育、退化、修复和再生的机制，最终 旨在促进肌肉骨骼系统疾病和损伤的诊断、治疗和预防。 我们中心还有一个无形的特点。尽管我们的肌肉骨骼项目在全国范围内都很强大， 宾夕法尼亚大学的生物医学研究社区规模庞大，种类繁多。因此，该中心是一个必不可少的 机制，以突出我们的成功和整个校园肌肉骨骼研究的重要性 至于机构领导力。为我们地区的肌肉骨骼研究人员发出强有力的声音是至关重要的 支持我们的集体和个人研究目标。通过这些方式，该中心--在 P30-已经成为并仍然是我们社会不可或缺的资源和倡导者。

The Penn Center for Musculoskeletal Disorders (PCMD) will continue to provide critical resources and programs to, and enhance research productivity of, investigators to address multidisciplinary research strategies for musculoskeletal problems. The overall goal of this Center is to promote cooperative interactions among investigators, accelerate and enrich the effectiveness and efficiency of ongoing research, foster new collaborations and new research, and ultimately, translate our research efforts into better and new therapies for musculoskeletal disorders. The Center theme is “Musculoskeletal Development, Disease, Injury and Repair” while addressing 3 Research Thrust areas. Our PCMD is the home for musculoskeletal research across the Penn campus and a hub for the musculoskeletal community across the region and neighboring states . One focus of our Center is to bridge themes, approaches, and paradigms across musculoskeletal tissues which may be overlooked when studying a single tissue. Since approaches used to evaluate mechanisms in one tissue could aid researchers in other areas, our Center will foster this critical cross-talk. To further focus, we will emphasize small animal models utilizing unique and sophisticated methods that cross length scales. The PCMD will provide unique expertise and tools to investigate musculoskeletal tissues across such scales. Thus, the primary overall Aims of this Center remain to enhance and advance the research productivity of investigators in musculoskeletal development, disease, injury and repair by providing: Aim 1: Innovation within critical resource core facilities in areas that cross disciplines, length scales, and hierarchies. These core facilities remain µCT Imaging, Biomechanics, and Histology; Aim 2: A pilot and feasibility grant program, with direct mentorship; and Aim 3: Educational and research enrichment programs, through which members can learn from national leaders and from each other. High quality musculoskeletal research is being conducted by many groups at Penn, in the region, and neighboring states. While many bring sophisticated approaches to musculoskeletal problems, few have the required expertise and facilities to perform the broad range of rigorous and specialized assays in their own labs. The Center will provide opportunities to integrate techniques to define mechanisms for tissue function, injury, development, degeneration, repair, and regeneration, with the ultimate goal of advancing diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system. There is also an intangible feature of our Center. Although our musculoskeletal program is strong nationally, the Penn biomedical research community is large and diverse. As such, the Center serves as an essential mechanism to highlight our successes and the importance of musculoskeletal research across campus, as well as to institutional leadership. Having a strong voice for musculoskeletal researchers for our region is critical to support our collective and individual research goals. In these ways, the Center - with essential support from the P30 - has become and remains an indispensable resource and advocate for our community.