Training in Oncology Population Sciences (TOPS)

项目总结/摘要 肿瘤学人口科学培训（TOPS）T32计划将培训博士后研究员进行 在T3和T4接口进行研究，将实验室的知识转化为实践和人口健康， 减轻癌症负担。在T3和T4界面进行转化研究的必要性源于 癌症结果的持续差异以及在可能的情况下 临床试验以及常规实践中发生的事情。TOPS计划将培养3名博士后研究员 与来自Dana-Farber/哈佛癌症中心7个机构的36名教师合作。 培训将使研究员掌握必要的技能，以应对所带来的挑战和机遇。 癌症治疗、精准医疗、电子健康的复杂性的巨大增长， 记录、移动的健康、机器学习和数据共享。TOPS计划有3个具体战略， 实现这一总体目标：1）通过以下方式培训调查所需的核心方法和技能： 课程作业和参加定期研讨会，讲习班和阅读; 2）集中精力进行研究 由一名或多名导师密切监督的项目;以及，3）专业技能培训 调查的先决条件，包括项目开发，赠款写作，演示，建设和工作 拥有多元化的团队，运营干式实验室并负责任地进行研究。 TOPS T32提案是对癌症结局研究中成功的R25 CA 092203计划的更新 培训（PCRT），在2002年至2017年期间培训了41名博士前和博士后研究员。TOPS将在- 由初级保健医生南希·基廷博士和医学肿瘤学家黛博拉·施拉格博士领导， 在PCOT指导委员会任职的有成就的以癌症为重点的人口科学家， 培养了许多成为独立研究人员的研究员。TOPS拟培养博士后 医学、护理学、行为科学、药学、经济学、临床医学等领域的学生 流行病学，卫生政策，信息学和工程学的职业生涯致力于癌症为重点的人口 科学该计划的核心是一个由36名教师导师和13名新兴导师组成的小组，他们具有以下方面的专业知识： 质量测量，患者、临床医生、社区和卫生系统一级干预措施的设计， 实用性试验，比较有效性研究，调查分析，行政和电子卫生 记录数据，以及优化实施的组织和行为策略方面的专业知识。年底 在为期两年的培训中，TOPS计划的参与者将充分掌握发射所需的技能， 在以癌症为重点的人口科学的独立研究生涯，并有机会获得核心资源， DF/HCC和哈佛转化研究培训的催化剂计划。TOPS联合董事和 由8名成员组成的指导委员会提供支持，该委员会包括来自7个机构的领导人， 人口基金/人口问题委员会成员和6名在人口科学方面有成就的调查员，他们将担任顾问。

PROJECT SUMMARY/ABSTRACT The Training in Oncology Population Sciences (TOPS) T32 program will train postdoctoral fellows to conduct research at the T3 and T4 interface to translate knowledge from the lab into practice and population health to reduce the burden of cancer. The need for translational research at the T3 and T4 interface stems from persistent disparities in cancer outcomes and implementation gaps between what is possible in the context of clinical trials and what happens in routine practice. The TOPS program will train 3 postdoctoral fellows each year in collaboration with 36 faculty from across the 7 institutions of the Dana-Farber/Harvard Cancer Center. Training will provide fellows with the skills necessary to address the challenges and opportunities brought about by the tremendous growth in the complexity of cancer care, precision medicine, electronic health records, mobile health, machine learning and data sharing. The TOPS program has 3 specific strategies to achieve this overarching objective: 1) training in core methods and skills necessary for investigation through coursework and participation in regular seminars, workshops and reading; 2) intensive focus on a research project with close supervision from one or more mentors; and, 3) training in professional skills that are prerequisite for investigation including project development, grant writing, presentation, building and working with diverse teams, running a dry-laboratory and the responsible conduct of research. The TOPS T32 proposal is a renewal of the successful R25CA092203 Program in Cancer Outcomes Research Training (PCORT), which trained 41 pre- and post-doctoral fellows between 2002 and 2017. TOPS will be co- led by Dr. Nancy Keating, a primary care physician, and Dr. Deborah Schrag, a medical oncologist, both accomplished cancer-focused population scientists who served on the PCORT Steering Committee and trained numerous fellows who have become independent researchers. TOPS intends to train postdoctoral students with degrees in the fields of medicine, nursing, behavioral science, pharmacy, economics, clinical epidemiology, health policy, informatics, and engineering for careers dedicated to cancer-focused population science. The core of the program is a group of 36 faculty mentors and 13 emerging mentors with expertise in quality measurement, design of patient, clinician, community and health system-level interventions, conduct of pragmatic trials, comparative effectiveness research, analysis of survey, administrative and electronic health record data, and expertise in organizational and behavioral strategies that optimize implementation. At the end of the two-year training, TOPS program participants will be well-equipped with the skills necessary to launch independent research careers in cancer-focused population science and have access to the core resources of the DF/HCC and the Harvard Catalyst program for translational research training. The TOPS co-directors and are supported by an 8-member Steering Committee that includes leaders from each of the 7 institutional members of the DF/HCC and 6 accomplished investigators in population science who will serve as Advisors.