Biostatistics Core

生物统计学核心：项目总结 生物统计学核心资源将提供全面的生物统计学和生物信息学咨询， 与约翰霍普金斯卵巢癌孢子的所有研究项目合作。核心成员 我将与项目调查人员合作开展广泛的活动，包括数据采集（包括 研究设计、目标的可行性、公众获取基因组信息的可用性和数据存储）， 统计质量控制（包括伪像检测和基因组技术数据的预处理），数据 分析（包括可视化、生物统计建模和协助撰写手稿），以及 如具体项目需要，开发创新的定制生物统计方法和工具。的 拟议的卵巢癌孢子生物统计学核心设在肿瘤学生物统计学部， 肿瘤学系的生物信息学，生物统计学和生物信息学的一个积极和致力于小组 教师，获得国家的最先进的设备和广泛的专业知识。核心资源 建立在积极参与约翰霍普金斯其他SPORE的核心成员所获得的专业知识基础上。核心 成员们对这个SPORE有着坚定的承诺，这源于：a）与 B）一个积极的和独立资助的议程， 在癌症遗传学和基因组学的协同项目，和c）表现出的兴趣和理解两者 生物学和分析学的问题和挑战。预计所有拟议项目都将利用这一点 Resource.

BIOSTATISTICS CORE: PROJECT SUMMARY The Biostatistics Core Resource will provide comprehensive biostatistics and bioinformatics consultation and collaboration to all Research Projects in the proposed Johns Hopkins Ovarian Cancer SPORE. Core members will work with project investigators across a wide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives, availability of public-access genomic information, and data storage), statistical quality control (including artifact detection and preprocessing of data from genomic technologies), data analysis (including visualization, biostatistical modeling, and assistance with manuscript writing), and development of innovative customized biostatistical methodologies and tools if required by specific projects. The proposed Ovarian Cancer SPORE Biostatistics Core is housed in the Division of Oncology Biostatistics and Bioinformatics of the Department of Oncology, an active and committed group of biostatistics and bioinformatics faculty members, with access to state-of-the art equipment and a broad range of expertise. This Core resource builds on expertise gained by Core members who actively participate in other SPOREs at Johns Hopkins. Core members have a strong commitment to this SPORE, stemming from: a) a history of collaboration with the investigators on this other research projects in ovarian cancer, b) an active and independently funded agenda of synergistic projects in cancer genetics and genomics, and c) a demonstrated interest and understanding of both the biological and analytical questions and challenges. All proposed Projects are anticipated to make use of this Resource.