Pathways to Cancer Therapeutics

项目摘要 新的和有针对性的癌症治疗方法的机会正在以指数级的速度增长。 然而，为了有效地利用这些机会，需要一批能够弥合分歧的研究人员 以实验室为基础的新治疗方法的识别与临床实际需求和 耐心治疗。目前，拥有这类技能的个人数量有限。癌症之路 治疗培训计划试图通过增加患有 在癌症生物学领域进行了强有力的培训，这是确定新的治疗方法的基础，世卫组织还 真正了解将科学发现转化为 诊所。该培训计划有两个关键目标：第一个目标是为博士后和博士后学员提供 对如何利用癌症生物学的基础研究来确定新药有严格的应用理解 目标和更有效的治疗策略。二是为学员提供了解 在临床上使用癌症治疗药物的挑战和实践。培训将集中在三个方面 它们是开发新的治疗方法的关键，也是癌症机构力量的领域 治疗：癌症代谢，肿瘤免疫学和微环境，基因组不稳定和 监管。为实现该方案的目标，提出了一系列多学科活动。(1)学员 将在26位主要导师中的一位的指导下参与一个指导研究项目 辛辛那提大学(UC)和辛辛那提儿童医院的10个基础科学和临床系 医疗中心(CCHMC)。导师有积极的、资金充足的研究项目和广泛的指导 经验。(2)受训者接受正规培训，包括授课、参加研讨会、道德规范 培训和职业发展活动。这些专业课可以获得临床和医疗专业证书 翻译研究。(3)学员参加临床肿瘤学活动。每个实习生都配对了一名 临床合作导师，具有与学员研究领域相关的专业知识。临床辅导员参加 制定学员研究项目和职业生涯规划。此外，受训人员参加肿瘤委员会/Grand 查房并与他们的共同导师一起参加临床阴影体验。培训计划是 由联合首席调查员和一名临床主任管理，并得到加州大学内部商业办公室的支持。 三个行政委员会提供项目评估和监督，支持严格的实习生选择 流程，确保培训的卓越，监督受训人员的进展，并确保受训人员代表种族 和科学上多元化的群体。培训计划在以下形式中有很强的机构承诺 包括直接财政支持、实习生福利和行政支持。机构方案和培训 方案导师和受训人员积极参与招募代表性不足的群体。培训 该计划要求美国国立卫生研究院为6名博士后和2名博士后实习生提供支持。

Project Summary The opportunities for new and targeted approaches to cancer treatment are growing at an exponential pace. However, to effectively harness these opportunities requires a pool of researchers who can bridge the divide between lab-based identification of new therapeutic approaches and actual clinical needs and practicalities of patient treatment. Currently the pool of individuals with such skills is limited. The Pathways to Cancer Therapeutics Training Program seeks to address this shortfall by increasing the number of individuals with a strong training in the areas of cancer biology that underlie identification of new therapeutic approaches, who also have a true understanding of the challenges and needs associated with translating scientific discovery into the clinic. The Training Program has two key goals: The first is to provide pre- and postdoctoral trainees with a rigorous and applied understanding of how basic research in cancer biology can be utilized to identify new drug targets and more effective therapeutic strategies. The second is to provide the trainees with an understanding of the challenges and practice of using cancer therapeutics in the clinic. The training will focus on three areas that are key to development of new therapeutic approaches and are areas of institutional strength in cancer therapy: cancer metabolism, tumor immunology and the microenvironment, and genome instability and regulation. A series of multidisciplinary activities are proposed to achieve the goals of the Program. (1) Trainees will participate in a mentored research project under the direction of one of 26 primary mentors who come from 10 basic science and clinical departments across the University of Cincinnati (UC) and Cincinnati Children’s Medical Center (CCHMC). The mentors have active, well-funded research programs and extensive mentoring experience. (2) Trainees undertake formal training that includes didactic coursework, attending seminars, ethics training and career development activities. The specialized classes lead to a Certificate in Clinical and Translational Research. (3) Trainees participate in activities in clinical oncology. Each trainee is paired with a clinical co-mentor with expertise related to the trainee’s research area. The clinical co-mentor participates in the development of the trainee research project and career plan. In addition, trainees attend Tumor Boards/Grand Rounds and participate in clinical shadowing experiences with their co-mentor. The Training Program is administered by Co-Principal Investigators and a Clinical Director with support from business offices within UC. Three administrative committees provide program evaluation and oversight, support a rigorous trainee selection process, ensure excellence in training, monitor trainee progress and ensure that trainees represent an ethnically and scientifically diverse group. There is a strong institutional commitment to the Training Program in the form of direct financial support, trainee benefits and administrative support. Institutional programs and Training Program mentors and trainees are actively involved in recruitment of underrepresented groups. The Training Program requests support from the NIH for 6 postdoctoral and 2 predoctoral trainees.