Enhancement to Leak Free Non-Invasive Ventilation Mask for Infectious Patients

项目摘要/摘要 新冠肺炎、非典等传染性呼吸道疾病患者大量需要呼吸道 支持。经面罩无创正压通气(NPPV)是治疗多发性硬化症的合适方法 可以带来比插管更好的结果的患者。此外，用于NPPV的设备(如 CPAP机器)广泛可用，使NPPV非常适合应对疫情和流行病。 不幸的是，NPPV口罩通过传播受污染的气雾剂增加了疾病传播的风险 面罩密封圈漏水。这使医护人员和其他患者面临更高的风险，并可能 阻碍遏制传染病暴发的努力。该计划的目标是开发一种 创新的NPPV患者接口，消除了通过面罩密封的受污染气雾剂的泄漏。 我们建议改进Creare的新型无泄漏口罩技术，使其更容易和更实用 在重症监护环境中。我们的设备将具有成本效益，并可与现有CPAP机器广泛集成 在医院里使用。这将使NPPV疗法在保护健康的同时广泛应用于感染患者。 护理人员和其他病人。这项技术将成为治疗患者的关键工具，同时防止 在医院环境中传播传染性呼吸道疾病。在第一阶段计划中，我们将演示 通过构建和测试实验室原型，我们增强的技术的可行性。

PROJECT SUMMARY/ABSTRACT A large number of patients with infectious respiratory diseases such as COVID-19 and SARS require respiratory support. Noninvasive Positive Pressure Ventilation (NPPV) via a mask is an appropriate treatment for many patients that can lead to better outcomes than intubation. Additionally, the equipment used for NPPV (such as CPAP machines) is widely available, making NPPV well suited for responding to outbreaks and pandemics. Unfortunately, NPPV masks increase the risk of disease transmission by spreading contaminated aerosols leaking from the mask seal. This exposes health care workers and other patients to increased risk and can hamper efforts to contain outbreaks of infectious diseases. The objective of this program is to develop an innovative NPPV patient interface that eliminates the leakage of contaminated aerosols through the mask seal. We propose to enhance Creare's novel leak-free mask technology to make it easier and more practical to use in a critical care setting. Our device will be cost effective and integrate easily with existing CPAP machines widely used in hospitals. This will enable widespread use of NPPV therapy on infectious patients while protecting health care workers and other patients. This technology will be a critical tool for treating patients while preventing the spreading of infectious respiratory diseases in a hospital setting. In the Phase I program, we will demonstrate the viability of our enhanced technology through building and testing laboratory prototypes.