In Vivo Imaging Core

项目摘要：活体成像模块 范德比尔特视力研究中心(VVRC)包括对以下方面有浓厚兴趣的教职员工 辨别清醒动物视觉通路中的结构-功能和功能-认知关系， 包括非人灵长类和人类受试者。VVRC在活体成像模块中的用途是 为所有利用动物的非侵入性成像研究提供全面的资源，包括 人类灵长类动物，或人类受试者。该模块使调查人员和他们的工作人员能够访问最先进的 活体动物和人体成像设施、离线分析和技术专长，通过补贴 利用范德比尔特大学成像科学研究所(VUIIS)的奖学金。VUIIS有一个核心 与基于物理学进展开发新成像技术有关的研究计划， 工程学和计算机科学。除了高场核磁共振和磁共振波谱，超声波、光学和 对于人类受试者的其他模式，VUIIS为小动物和非人类提供了最先进的选择 所有形式的灵长类成像。这些资源由人体成像中心提供 (由模块主任Seth Smith执导)和小动物成像中心(CSAI)。奖学金 该系统由VUMC研究办公室实施，并通过 VUmc iLab会计系统。在本供资周期中，有11人使用了体内成像模块 使用这项服务撰写了89份出版物的调查人员，通过 发放和使用35个奖学金。在下一个周期中，我们预计36个中的17个将适度到广泛使用 调查人员。体内成像模块，安装在集中位置，足以容纳众多独立的 非侵入性成像平台，由副教授Seth Smith博士指导。使用资源和 部分由该核心机制支持的人员，VVRC In Vivo成像模块将(1)开发和 将先进的多模式成像技术应用于人类视觉及其处理和耦合的研究 神经科学，(2)开发和部署一套用于动物视觉研究的多模式成像工具 模型，以及(3)开发成像信息学、人工智能和机器学习的基础设施 最先进的“大视界数据”分析。这些服务和资源将扩大 NEI资助的VVRC调查人员进行实验，扩大对参与的学生和研究员的培训 ，并通过提供复杂、高分辨率和多样化的成像来促进协作 为那些否则不会拥有这种能力的人提供平台，包括职业生涯早期的远见科学家和 临床医生--为实验室争取外部资金的科学家。

PROJECT SUMMARY: IN VIVO IMAGING MODULE The Vanderbilt Vision Research Center (VVRC) includes faculty investigators with a strong interest in discerning structure-function and function-cognition relationships in the visual pathways in awake animals, including non-human primates, and human subjects. The purpose of the VVRC In Vivo Imaging Module is to provide a comprehensive resource for all non-invasive imaging research that utilizes animals, including non- human primates, or human subjects. This module gives investigators and their staff access to state-of-the-art live animal and human imaging facilities, offline analysis, and technical expertise through subsidized scholarship use of the Vanderbilt University Institute of Imaging Science (VUIIS). The VUIIS has a core program of research related to developing new imaging technology based on advances in physics, engineering, and computer science. In addition to high-field MRI and MR spectroscopy, ultrasound, optical and other modalities in human subjects, the VUIIS offers state-of-the-art options for small animal and non-human primate imaging in all modalities. These resources are provided through the Center for Human Imaging (Directed by Module Director Seth Smith) and the Center for Small Animal Imaging (CSAI). The scholarship system is implemented by the VUMC Office of Research and is utilized instead of a discount or co-pay via the VUMC ILab accounting system. In the current funding cycle, the In Vivo Imaging Module was used by 11 investigators who authored 89 publications using the service, and saved our investigators $2229,325 through issuance and utilization of 35 scholarships. In the next cycle, we expect moderate to extensive use by 17 of 36 investigators. The In Vivo Imaging Module, housed in centralized locations sufficient for numerous independent non-invasive imaging platforms, is directed by Associate Professor Seth Smith, PhD. Using resources and personnel supported in part by this Core mechanism, the VVRC IN Vivo Imaging Module will (1) develop and deploy advanced, multi-modal imaging technologies to the study of human vision, its processing, and coupled neuroscience, (2) develop and deploy a multi-modal set of imaging tools for the study of vision in animal models, and (3) develop Infrastructure for imaging informatics, artificial intelligence, and machine learning for state-of-the-art analysis of “big vision data”. These services and resources will enhance the scope of experimentation NEI-funded VVRC investigators conduct, expand the training of students and fellows involved in vision science, and promote collaboration by providing sophisticated, high-resolution and diverse imaging platforms to those who otherwise would not have such capabilities, including early-career vision scientists and clinician-scientists competing for extramural funding for their laboratories.