Animal Models & Imaging Facility (AMIF)

项目摘要/摘要 动物模型和成像设备(AMIF)提供最先进的临床前分子成像服务 在西弗吉尼亚大学进行生物医学研究。疾病的动物模型是研究疾病的关键工具 促进对影响疾病进展的因素的理解的翻译研究项目 疾病和潜在治疗目标的影响。癌症研究人员尤其需要能够 实时研究肿瘤在微环境中的生长和转移，并在活体动物中 确定启动肿瘤形成、促进癌症进展或影响治疗反应的事件。 作为生物医学卓越研究肿瘤微环境中心(TME Cobre)的一部分，AMIF拥有 通过增加新的放射设备，扩大了其成像和临床前治疗能力 治疗，电子顺磁共振和磁共振成像，以及高分辨率显微 计算机断层扫描。AMIF是校园中唯一可以提供这些纵向、非侵入性 具有足够分辨率的成像研究，可在小动物模型中工作。这个核心的长期目标是 是(1)在现有的核心设施中建立新的治疗和成像资源，以支持转化性 针对肿瘤微环境的研究项目以及(2)为研究人员提供培训和支持 利用临床前模型研究癌症生物学。此TME Cobre支持的核心将与其他 机构发展奖(IDEA)资助的项目，包括其他科布雷项目，IDEA网络 生物医学卓越研究奖(INBRE)和IDEA临床与翻译研究奖(IDEA-CTR) 提高研究竞争力，改进治疗，解决健康差距，特别是癌症方面的差距。 AMIF提供了与西弗吉尼亚大学其他中心协作的机会，从而产生最广泛的影响 科布雷投资公司。此外，它与患者衍生的异种移植核心设备在这个TME Cobre中集成在一起 通过使用初级患者样本的小鼠模型的研究来应用。此外，它还高度连接 到流式细胞仪单细胞分析核心设施，将提供回收细胞的下游分析 来自异种移植模型。AMIF致力于指导并参加技术研讨会系列 与其他科布雷核心合作，加强科布雷地区的教育和合作- 支持的倡议。

PROJECT SUMMARY/ABSTRACT The Animal Models & Imaging Facility (AMIF) provides state-of-the-art, preclinical molecular imaging services for biomedical research at West Virginia University. Animal models of disease are a critical tool for the translational research projects that promote understanding of the factors that influence the progression of disease and the impact of potential therapeutic targets. Cancer researchers, in particular, need to be able to study tumor growth and metastasis in the context of the microenvironment in real time and in living animals to determine the events that initiate tumorigenesis, promote cancer progression or impact response to treatment. As part of the Tumor Microenvironment Center of Biomedical Research Excellence (TME CoBRE), the AMIF has expanded its imaging and preclinical treatment capabilities with the addition of new equipment for radiation therapy, electron paramagnetic resonance and magnetic resonance imaging, and for high-resolution micro computed tomography. The AMIF is the only facility on campus that can offer these longitudinal, non-invasive imaging studies with sufficient resolution for working in small animal models. The long-term goals of this core are to (1) establish novel treatment and imaging resources in an existing core facility to support translational research projects targeting the tumor microenvironment and (2) provide training and support for investigators using preclinical models to study cancer biology. This TME CoBRE-supported core will synergize with other Institutional Development Award (IDeA)-funded projects including other CoBRE projects, the IDeA Network of Biomedical Research Excellence (INBRE), and the IDeA Clinical and Translational Research Award (IDeA-CTR) to enhance research competitiveness, improve therapy, and address health disparities, particularly in cancer. The AMIF provides opportunities for collaboration with other Centers at WVU resulting in the broadest impact of CoBRE investment. Further, it is integrated with the Patient-Derived Xenograft Core Facility in this TME CoBRE application through the study of mouse models using primary patient samples. In addition, it is highly connected to the Flow Cytometry Single Cell Analysis Core Facility that will provide downstream analysis of cells recovered from xenograft models. The AMIF is committed to mentoring and participates in the Technology Seminar Series in partnership with the other CoBRE Cores to enhance both education and collaboration across the CoBRE- supported initiatives.