Imaging Core

成像核心

• 批准号: 10709268
• 负责人: Karen H Martin
• 金额: $ 22.44万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709268
• 关键词: 3-Dimensional; Address; Animal Disease Models; Animal Model; Animals; Award; Biomedical Research; Cancer Biology; Cancer Patient; Cell model; Cells; Centers of Research Excellence; Clinical Research; Collaborations; Communities; Complex; Contract Services; Core Facility; Data Analyses; Dedications; Detection; Development; Disease Progression; Education; Ensure; Equipment; Experimental Designs; Extramural Activities; Flow Cytometry; Funding; Goals; Health Sciences; Image; In Vitro; Individual; Institution; Investments; Journals; Light; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Mentors; Microscope; Microscopy; Modeling; Monitor; Organ; Perfusion; Phase; Postdoctoral Fellow; Pre-Clinical Model; Program Sustainability; Publications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resources; Rodent Model; Series; Services; Signal Pathway; Students; Technology; Training; Training Programs; Translational Research; Tumor Biology; Tumor Volume; Universities; Wages; West Virginia; cancer care; design; experience; extracellular; fluorescence imaging; health disparity; human model; imaging facilities; improved; in vivo imaging; instrumentation; intravital imaging; member; mouse model; multi-photon; new technology; new therapeutic target; novel; operation; pre-clinical; programs; recruit; single cell analysis; structural imaging; success; synergism; therapeutic target; tool; training opportunity; treatment response; tumor; tumor growth; tumor microenvironment; ultra high resolution; ultrasound; whole animal imaging

Project Abstract/Summary – Imaging Core The Imaging Core provides cutting-edge equipment and training opportunities to support the labs in the Tumor Microenvironment Center of Biomedical Research Excellence (TME CoBRE). Cellular and animal models of disease are important tools for translational research projects that promote understanding of the factors that influence the initiation and detection of tumors, progression of disease and the impact of potential therapeutic targets. Project Leaders will have access to imaging equipment that spans from super resolution intracellular imaging through to whole animal imaging. Rather than establish a new imaging core to support the proposed projects, the West Virginia University Health Sciences Center (WVU HSC) has chosen to expand the successful, existing imaging facilities through significant institutional commitments to provide the new equipment needed by the PLs that will yield high scientific impact. During Phase I, the Imaging Core expanded with addition of a light sheet microscope for 3D fluorescent imaging of entire tumors or organs from rodent models, a multiphoton microscope for high resolution, intravital imaging, an MRI for non-invasive structural imaging in mouse models and a new micro-ultrasound for measuring tumor volume and perfusion. This institutional commitment has also included new space dedicated to the core, as well as support for salaries and service contracts. These investments allow well-established cores to incorporate novel and cutting-edge technologies, as well as to continue providing established services to the research community. Support of the existing core resources provides efficiency of operations since the same staff will be able to operate and manage the new instrumentation. The long-term goals of this core are to (1) establish novel treatment and imaging resources in an existing core facility to support translational research projects targeting the tumor microenvironment and (2) provide training and support for investigators using preclinical models to study cancer biology. All of the Project Leaders in Phase I (including the Project Leaders in this application) have been supported by the Imaging Core, and this need will extend into Phase II. This TME CoBRE-supported core will synergize with other Institutional Development Award (IDeA)-funded projects including other CoBRE projects, the IDeA Network of Biomedical Research Excellence (INBRE), and the IDeA Clinical and Translational Research Award (IDeA-CTR) to enhance research competitiveness, improve therapy, and address health disparities, particularly in cancer. The Imaging Core provides opportunities for collaboration with other Centers at WVU, resulting in the broadest impact of CoBRE investment. Further, it is highly connected to the Flow Cytometry Single Cell Analysis Core Facility that will provide additional analysis tools for characterizing the tumor microenvironment. The Imaging Core is committed to mentoring and participates in the Technology Seminar Series in partnership with the other CoBRE Cores to enhance both education and collaboration across the CoBRE-supported initiatives.

项目摘要/总结-成像核心 成像核心提供尖端设备和培训机会，以支持肿瘤实验室 微环境卓越生物医学研究中心（TME CoBRE）细胞和动物模型 疾病是转化研究项目的重要工具，这些项目促进了对 影响肿瘤的发生和检测、疾病的进展以及潜在治疗药物的影响。 目标的项目负责人将有机会获得成像设备，从超分辨率细胞内 成像到整个动物成像。而不是建立一个新的成像核心，以支持拟议的 项目，西弗吉尼亚大学健康科学中心（WVU HSC）选择扩大成功， 现有的成像设施，通过重大的机构承诺，提供所需的新设备， 将产生高科学影响力的PL。在第一阶段，成像核心通过添加灯光进行扩展 用于啮齿动物模型的整个肿瘤或器官的3D荧光成像的薄片显微镜， 用于高分辨率活体成像的显微镜，用于小鼠模型非侵入性结构成像的MRI 以及一种新的微型超声波，用于测量肿瘤体积和灌注。这一体制承诺还 包括核心专用的新空间，以及对薪金和服务合同的支助。这些 投资使成熟的核心能够融入新的和尖端的技术， 继续为研究界提供既定的服务。现有核心资源的支助 提供运营效率，因为相同的工作人员将能够操作和管理新的 仪器仪表该核心的长期目标是（1）建立新的治疗和成像资源， 现有的核心设施，以支持针对肿瘤微环境的转化研究项目，以及（2） 为使用临床前模型研究癌症生物学的研究人员提供培训和支持。所有项目 第一阶段的负责人（包括本申请中的项目负责人）得到了成像核心的支持， 这种需求将延伸到第二阶段。这一由CoBRE支持的TME核心将与其他机构协同工作， 发展奖（IDEA）资助的项目，包括其他CoBRE项目，IDEA生物医学网络 卓越研究奖（INBRE）和IDEA临床和转化研究奖（IDEA-CTR），以提高 研究竞争力，改善治疗，解决健康差距，特别是癌症。成像 核心提供与西弗吉尼亚大学其他中心合作的机会，从而产生最广泛的影响， Cobre投资。此外，它与流式细胞术单细胞分析核心设施高度相关， 将为表征肿瘤微环境提供额外的分析工具。成像核心是 致力于指导并与其他CoBRE合作参与技术研讨会系列 核心，以加强教育和合作，在CoBRE-supported倡议。