Administrative Core

为了响应多机构团队组建胶质母细胞瘤的资金机会公告 治疗学网络（GTN）的基础科学家和临床/翻译研究人员来自三个机构， 丹娜-法伯/哈佛癌症中心与斯坦福大学癌症中心的同行联手 中心打造“哈佛/斯坦福大学GTN”。GTN研究计划包括三个项目， 行政核心、药理学和基因组成像核心以及拟议的网络 协调中心。行政核心将设在布里格姆妇女医院， 哈佛/斯坦福大学GTN的上级组织，并将作为协调中心和枢纽， 四个机构组成的程序和所有的互动与现有的P30支持的资源，临床 审判核心将协调这一复杂结构的内部和外部组成部分， 成人胶质母细胞瘤的多项目、跨学科和跨机构药物开发研究。核心 人员包括一名GTN首席研究员、哈佛/斯坦福大学GTN机构的三名研究中心负责人， 两名科学共同管理员，一名项目协调员，两名赠款专家和一名行政助理。 行政核心有五个具体目标。在第一个目标中，核心将开发和参与一个 多学科内部咨询委员会，对整个哈佛/斯坦福大学GTN提供关键监督 程序.在第二个目标中，核心将定期组织主要利益攸关方会议， 协作、故障排除和进度监控。在第三和第四个目标中，核心将保持 一个跨机构的计划，定期，内部和外部的电子通信， 哈佛/斯坦福大学项目和核心共同负责人、临床试验者、GTN指导委员会、NCC、NCI 项目官员和行业合作伙伴。在第五个目标中，核心将与机构领导人接触， 哈佛和斯坦福将在整个哈佛/斯坦福大学GTN项目中促进多样性和包容性。的 行政核心负责人，Tracy Batchelor，医学博士，将担任本研究的总体主要研究者， 哈佛/斯坦福大学GTN项目，达纳-法伯癌症研究所的研究中心负责人（帕特里克 Wen，M.D.），马萨诸塞州总医院（伊莎贝尔Arrillaga，医学博士，Ph.D.），和斯坦福大学（米歇尔 Monje，医学博士，Ph.D.）。达纳-法伯/哈佛癌症中心的跨机构管理团队和 斯坦福大学癌症中心在其他多中心、多项目、NCI-Sponsored 神经胶质瘤研究项目。

In response to a Funding Opportunity Announcement for multi-institutional teams to form a Glioblastoma Therapeutics Network (GTN) basic scientists and clinical/translational investigators from three institutions in the Dana-Farber/Harvard Cancer Center have joined forces with their counterparts in the Stanford Cancer Center to create the “Harvard/Stanford GTN”. The GTN study plan features three Projects an Administrative Core, a Pharmacological and Genomic Imaging Core and a proposed Network Coordinating Center (NCC). The Administrative Core will be based at Brigham and Women’s Hospital, the parent organization for the Harvard/Stanford GTN, and will serve as the coordinating center and hub for the four institutions comprising the program and all interactions with existing P30-supported resources for clinical trials. The core will coordinate internal and external components of this complex structure to foster and support multi-project, inter-disciplinary, and inter-institutional drug development research in adult glioblastoma. Core personnel include one GTN Principal Investigator, three Site Leads at the Harvard/Stanford GTN institutions, two scientific co-administrators, a program coordinator, two grants specialists, and an administrative assistant. There are five Specific Aims in the Administrative Core. In the First Aim, the core will develop and engage a multidisciplinary Internal Advisory Board to provide critical oversight of the overall Harvard/Stanford GTN program. In the Second Aim, the core will organize regular meetings of key stakeholders to foster collaboration, troubleshooting, and monitoring of progress. In the Third and Fourth Aims, the core will maintain a trans-institutional program for regular, internal and external electronic communication among Harvard/Stanford project and core co-leads, clinical trialists, the GTN Steering Committee, the NCC, NCI program officials, and industry partners. In the Fifth Aim, the core will engage with institutional leaders at Harvard and Stanford to promote diversity and inclusion throughout the Harvard/Stanford GTN program. The Administrative Core Leader, Tracy Batchelor, M.D., will serve as the overall Principal Investigator of the Harvard/Stanford GTN program with able assistance from Site Leads at Dana-Farber Cancer Institute (Patrick Wen, M.D.), Massachusetts General Hospital (Isabel Arrillaga, M.D., Ph.D.), and Stanford University (Michelle Monje, M.D., Ph.D.). This trans-institutional administrative team at Dana-Farber/Harvard Cancer Center and Stanford Cancer Center have worked together effectively on other multi-center, multi-project, NCI-sponsored glioma research projects.