Cancer Neuroscience Training Program

癌症神经科学培训计划

• 批准号: 10714321
• 负责人: Tracy T Batchelor
• 金额: $ 49.62万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714321
• 关键词: Malignant Neoplasms; Neurosciences; Training Programs

Abstract Contemporary new technologies such as optogenetics and single cell genomics show that electrically active neurons stimulate growth of adult and pediatric gliomas. Conversely, cancers and cancer therapies alter nervous system form and function (e.g., cancer therapy-related cognitive impairment colloquially known as ‘‘chemobrain’’ or ‘‘chemofog”). The two-way dialogue between tumors and the nervous system defines an emerging new scientific discipline termed “Cancer Neuroscience”. The Department of Neurology at Brigham and Women’s Hospital (BWH), together with the Department of Neurobiology at Harvard Medical School (HMS), propose an integrative, first-in-kind postdoctoral training program in this new field. The Program will be co-led by a clinician scientist, Tracy Batchelor, M.D. (Chair of Neurology at BWH) and a basic scientist Michael Greenberg, Ph.D. (co-director, Harvard Brain Science Initiative). A faculty of 29 mentors will be drawn from the Dana-Farber/Harvard Cancer Center and from the Harvard Brain Science Initiative. This will be a basic science program. Candidates with Ph.D. and/or M.D. degrees will be eligible but there will be no clinical training. We request support for 6 postdoctoral fellows per year to serve 2-year appointments. The Program will foster both scientific development and professional development of these trainees. For Scientific Development, the Program will bring doctorate level basic scientists with skill sets in neural development, electrophysiology, neural circuitry, optogenetics, brain metabolism and neurochemistry into the laboratories of clinical/translational investigators working on primary and also metastatic cancers of the brain. For laboratory research, fellows will be taught to identify important questions and approaches that will move the field forward and provide translational opportunities to impact cancer treatment. For professional development, we will provide trainees with (i) opportunities to refine and enhance their grantsmanship and scientific communication skills; (ii) individual Development Plans; (iii) individual postdoctoral mentoring committees, and (iv) customized opportunities for trainees to acquire experience in mentoring and teaching depending on their career goals. The program Director and co-Director will work closely with a Training Oversight Committee and an External Advisory Board. Collaborative relationships with Morehouse School of Medicine and with the University of Massachusetts-Boston (the largest center of higher education for minority students in New England) will help identify ways to recruit underrepresented minorities into the program and to maintain a welcoming environment for these trainees. Additional strategies to measure trainee satisfaction, quantify outcomes, and evaluate the effectiveness of the program will include annual surveys from trainees and mentors, as well as exit and alumni interviews. Institutional support in the form of state-of-art core facilities, technology platforms and funds to support T32-specific training activities and yearly EAB meetings will significantly enhance the training program.

抽象的 当代新技术（例如光遗传学和单细胞基因组学）表明电活动 神经元刺激成人和小儿神经胶质瘤的生长。相反，癌症和癌症疗法改变了 神经系统形式和功能（例如，与癌症治疗相关的认知障碍通俗地称为 ``Chemobrain''或``Chemofog'）。肿瘤和神经系统之间的双向对话定义了 新兴的新科学学科称为“癌症神经科学”。杨百翰神经病学系 和妇女医院（BWH），以及哈佛医学院的神经生物学系 （HMS），建议在这个新领域的一项综合，实物的博士后培训计划。该程序将是 由临床科学家Tracy Batchelor，医学博士（BWH的神经病学主席）和基础科学家Michael共同领导 格林伯格博士（哈佛大学脑科学倡议联合导演）。由29位导师的教师从 Dana-Farber/Harvard Cancer Center和Harvard Brain Science Initiative。这将是一门基础科学 程序。拥有博士学位的候选人和/或M.D.学位将符合条件，但不会进行临床培训。 我们要求支持每年6个博士后研究员服务2年的约会。该程序将 培养这些受训者的科学发展和专业发展。对于科学 开发，该计划将为博士学位的基础科学家带来神经发展方面的技能， 电生理学，神经循环，光遗传学，脑代谢和神经化学作用 从事大脑原发性和转移性癌症的临床/翻译研究人员。用于实验室 研究，研究员将被教导确定重要的问题和方法，这些问题和方法将使领域向前发展 并提供影响癌症治疗的转化机会。对于专业发展，我们将 为受训者提供（i）优化和增强他们的赠款和科学沟通的机会 技能； （ii）个人发展计划； （iii）个体的博士后心理委员会，以及（iv）定制 学员的机会，取决于他们的职业目标。 计划主任兼联合主任将与培训监督委员会紧密合作 外部顾问委员会。与莫尔豪斯医学院以及与 马萨诸塞大学波士顿大学（新的高等教育中心 英格兰）将有助于确定招募代表性不足的少数民族的方法，并保持 这些受训者欢迎环境。衡量受训者满意度的其他策略，量化 成果，评估该计划的有效性将包括培训和 导师以及退出和校友访谈。以最先进的核心设施形式的机构支持， 支持T32特定培训活动和年度EAB会议的技术平台和资金将 显着增强培训计划。