Examining domains of trauma response and their link to chronic pain

项目总结/摘要 身体和情感创伤与许多负面健康影响有关，包括近三倍的 报告慢性疼痛的几率增加。研究表明，创伤后慢性疼痛是在 通过至少三类因素（即，心理学、神经生物学和社会学），这可能会使早期 识别弱势群体。然而，目前的数据用于阐明潜在的机制， 创伤性事件对疼痛发展的影响有限。获取识别早期风险的纵向数据 因素和脆弱性的痛苦是特别困难的。此外，很少有研究评估了 社会感知和对负面社会刺激的敏感性（即，“社会敏感性”）作为潜在的中介， 创伤暴露于身体疼痛。目前的建议试图通过整合这些限制来解决这些问题。 多个领域和层次的分析，以检查创伤反应对发展的影响， 慢性疼痛的持续性。该项目将首先利用现有的纵向和实验数据收集 作为提高对创伤后恢复的认识（AURORA）研究（NIMH U 01 MH 110925）的一部分， 探索心理和神经生物学对创伤后疼痛脆弱性的贡献。该项目将 然后通过对参与者进行实验研究， 不同的创伤史和临床疼痛特征，以检查社会 知觉和敏感性、创伤后遗症和疼痛。该研究将利用实验范式 测量情绪感知，观点采择和社会敏感性，并评估这些社会处理 创伤后遗症和疼痛特征之间的关联的潜在介质的因素。的 还将评估社会感知和疼痛症状的调查措施之间的关联， 时间这项研究计划是一个更大的培训计划的一部分，允许候选人发展专业知识， 创伤和疼痛，纵向数据分析和实验方法;以及领导技能， 管理一个小的学习团队。候选人组建了一个专家指导团队， 在疼痛表型、创伤、实验方法学和统计分析方面拥有丰富的专业知识。 结合密歇根大学丰富的环境，该奖项将提供重点培训， 建立一个独特的专业知识和独立的研究计划，重点是交叉点， 创伤和痛苦它还将为未来的资金提供关键的初步数据，专门用于推进我们的 在这一关键的研究领域的理解。

PROJECT SUMMARY/ABSTRACT Physical and emotional trauma are linked to numerous negative health effects, including a nearly three-fold increase in the odds of reporting chronic pain. Research suggests that post-traumatic chronic pain is preceded by at least three classes of factors (i.e., psychological, neurobiological, and social) that might allow for earlier identification of vulnerable individuals. Yet, current data used to elucidate potential mechanisms linking traumatic events to pain development have been limited. Capturing longitudinal data that identifies early risk factors and vulnerabilities to pain is particularly difficult. Additionally, few studies have evaluated the role of social perception and sensitivity to negative social stimuli (i.e., ‘social sensitivity’) as potential mediators linking trauma exposure to physical pain. The current proposal seeks to address these limitations by integrating multiple domains and levels of analysis to examine the impact of traumatic response on the development and persistence of chronic pain. The project will first leverage existing longitudinal and experimental data collected as part of the Advancing Understanding of RecOvery afteR traumA (AURORA) study (NIMH U01MH110925) to explore psychological and neurobiological contributions to post-traumatic pain vulnerability. The project will then expand beyond the data available in AURORA by conducting an experimental study in participants with varying histories of trauma and clinical pain characteristics to examine the associations between social perception and sensitivity, trauma sequelae, and pain. The study will utilize experimental paradigms measuring emotion perception, perspective-taking, and social sensitivity and assess these social processing factors as potential mediators of the association between trauma sequelae and pain characteristics. The association between survey measures of social perception and pain symptoms will also be assessed over time. This research proposal is part of a larger training plan that allows the candidate to develop expertise in trauma and pain, longitudinal data analysis, and experimental methodology; and leadership skills through management of a small study team. The candidate has assembled a mentorship team of experts with extensive expertise in pain phenotyping, trauma, experimental methodology, and statistical analysis. Combined with the rich environment of the University of Michigan, this award will provide focused training to establish a unique niche of expertise and an independent research program focused on the intersection of trauma and pain. It will also provide critical preliminary data for future funding dedicated to advancing our understanding in this critical area of research.