PTSD AND SLEEP FOLLOWING SEVERE ACCIDENTAL INJURY

创伤后应激障碍或创伤后应激障碍是生活中常见的后遗症 具有威胁性的压力源，与显著的慢性和 心理社会病态。严重事故是常见的生命威胁 然而，与意外伤害有关的创伤后应激障碍仍在调查中。 睡眠障碍是创伤后应激障碍的一个不可分割的特征，并可能在 失调症的发展和维持。 我们建议研究创伤后应激障碍症状及其与睡眠的关系。 严重意外伤害后急性期的现象。 在一个地区发生危及生命的事故而住院的患者 将对创伤中心进行筛查，如果合适，还将对创伤后应激障碍和其他 将对精神病学和医学参数进行评估。病人的睡眠 然后用便携式多导睡眠记录仪进行记录。 睡眠措施与创伤后应激障碍症状严重程度的关系将是 下定决心。将作出努力以减少 医学/外科因素通过筛查程序影响睡眠。 这些因素以及其他因素之间可能存在的关系 精神变量对睡眠措施的影响，将在分析中进行探索。 这项研究的最终目的是评估睡眠与睡眠的关系 巩固和减轻创伤后应激障碍症状。有症状的病人会被 随机分配到7天的催眠药物疗程与 在接受临床治疗的同时服用安慰剂，治疗2周 相位。睡眠、创伤后应激障碍和情绪症状将在 开始并在治疗阶段结束时。决赛 对症状严重程度和功能调整的研究评估将 发生在1个月后(从基线评估开始6周) 原创主题。

Post-traumatic Stress Disorder or PTSD is a common sequela of life threatening stressors and is associated with significant chronicity and psychosocial morbidity. Severe accidents are common life threatening events yet PTSD related to accidental injury remains under-investigated. Sleep disturbance is an integral feature of PTSD and may have a role in the development and maintenance of the disorder. We propose to study PTSD symptoms and their relationship to sleep phenomena during an acute phase following severe accidental injury. Patients hospitalized for life threatening accidents at a regional Trauma Center will be screened, and if appropriate, PTSD and other psychiatric and medical parameters will be evaluated. Patients' sleep will then be recorded with a portable polysomnographic unit. Associations of sleep measures with PTSD symptom severity will be determined. Attempts will have been made to reduce the impact of medical/surgical factors on sleep through screening procedures. Possible relationships of these factors, as well as that of other psychiatric variables to sleep measures, will be explored in analyses. The final aim of the study is to evaluate the relationship of sleep consolidation and PTSD symptom reduction. Symptomatic patients will be randomly assigned to a 7 day course of hypnotic medication versus placebo while receiving clinical management, during a 2 week treatment phase. Sleep, PTSD, and mood symptoms will be assessed prior to initiating and at the completion of the treatment phase. The final study evaluation for symptom severity and functional adjustment will occur 1 month later (6 weeks from baseline assessments) for all of the original subjects.