PTSD AND SLEEP FOLLOWING SEVERE ACCIDENTAL INJURY

创伤后应激障碍或PTSD是一种常见的后遗症的生活 威胁性压力源，并与显著的慢性和 心理社会病态 严重的事故通常会危及生命 然而，与意外伤害有关的PTSD事件仍然没有得到充分的研究。 睡眠障碍是创伤后应激障碍的一个重要特征， 疾病的发展和维持。 我们建议研究创伤后应激障碍症状及其与睡眠的关系 严重意外伤害后急性期的现象。 因危及生命的事故而住院的患者， 创伤中心将进行筛选，如果合适，PTSD和其他 将对精神和医疗参数进行评估。 患者睡眠 然后用便携式多导睡眠仪记录。 睡眠测量与PTSD症状严重程度的关联将被 测定 将努力减少 医学/手术因素对睡眠的影响。 这些因素之间的可能关系，以及其他因素之间的可能关系。 精神病学变量的睡眠措施，将在分析中探讨。 本研究的最终目的是评估睡眠与 巩固和PTSD症状减轻。 有症状的患者将 随机分配至7天的催眠药物疗程， 在2周治疗期间，接受临床管理的同时接受安慰剂 相位 睡眠，创伤后应激障碍和情绪症状将在 在治疗阶段的开始和结束时。 最终 对症状严重程度和功能调整研究评价将 发生在1个月后（基线评估后6周）， 原创主题

Post-traumatic Stress Disorder or PTSD is a common sequela of life threatening stressors and is associated with significant chronicity and psychosocial morbidity. Severe accidents are common life threatening events yet PTSD related to accidental injury remains under-investigated. Sleep disturbance is an integral feature of PTSD and may have a role in the development and maintenance of the disorder. We propose to study PTSD symptoms and their relationship to sleep phenomena during an acute phase following severe accidental injury. Patients hospitalized for life threatening accidents at a regional Trauma Center will be screened, and if appropriate, PTSD and other psychiatric and medical parameters will be evaluated. Patients' sleep will then be recorded with a portable polysomnographic unit. Associations of sleep measures with PTSD symptom severity will be determined. Attempts will have been made to reduce the impact of medical/surgical factors on sleep through screening procedures. Possible relationships of these factors, as well as that of other psychiatric variables to sleep measures, will be explored in analyses. The final aim of the study is to evaluate the relationship of sleep consolidation and PTSD symptom reduction. Symptomatic patients will be randomly assigned to a 7 day course of hypnotic medication versus placebo while receiving clinical management, during a 2 week treatment phase. Sleep, PTSD, and mood symptoms will be assessed prior to initiating and at the completion of the treatment phase. The final study evaluation for symptom severity and functional adjustment will occur 1 month later (6 weeks from baseline assessments) for all of the original subjects.