HABS-HD - Core E - Disparities & Outreach Core

HABS-高清差异和外展核心(核心E)-摘要 《国家阿尔茨海默氏症项目法案》(NAPA)的主要目标之一是 和少数族裔人口。然而，在理解不同的原因方面存在很大差距 少数族裔中阿尔茨海默病(AD)和AD相关疾病(ADRD)的增加 人口的存在，主要是因为少数群体在老龄化研究中的代表性不足。社区 接触和外展被认为是招募不同人群的最成功的战略之一 投入到研究中。达拉斯福斯沃斯(DFW)大都会建筑群，健康与老龄化大脑研究-健康 差异(HABS-HD)，目前反映了美国未来的种族/民族人口和理想的地理位置 同时研究非裔美国人(AA)、墨西哥裔美国人(MA；63%的 美国西班牙裔人口)和非西班牙裔白人(Nhw)。HABS-HD是第一个大规模、以社区为基础的 同时研究AT(N)定义的每个生物标记物的项目，与NIA Health保持一致 差异研究框架。HABS-HD的长期目标是建立针对特定人群的知情 NIA AD+ADRD研究呼吁精准医学提供新的治疗和预防策略 实施里程碑1.近10年来，HABS-HD建立了社区联系网络，并 使用以社区为基础的招聘方法建立良好的人际关系。这种强调外展的方法， 研究团队和社区中的主要利益相关者之间的参与和合作导致了 成功征聘2,000名参与者(n=1,000人，1,000人)，年龄在50岁及以上，纵向 后续工作正在进行中。根据UNTHSC机构资金，这一群体已扩大到包括1000人 AAS，招募工作将在本U19开始之前完成。作为拟议的U19的一部分，主要的 核心E的目标是进一步提高不同社区对研究和研究的认识和参与 提供外展基础设施，全面了解AD的发展和进展 以及整个生命过程中的ADRDS。为了实现这一目标，核心E将解决以下具体目标：目标 1：将HABS-HD队列的招募延长至30-49岁(每个种族/族裔群体500人)，保留现有 并招募新的参与者，以抵消人员流失。目标2：产生和传播教育 关于大脑老化在生命过程中的重要性以及在不同领域研究的重要性的材料 社区。目标3：与所有核心和项目协作，继续监测和确保所有 HABS-HD活动是按照NIA健康差距研究框架进行的。

HABS-HD DISPARITIES & OUTREACH CORE (CORE E) - ABSTRACT One of the primary goals of the National Alzheimer’s Project Act (NAPA) is to “improve outcomes for ethnic and racial minority populations.” However, substantial gaps in understanding the reasons for the disparate increase in Alzheimer’s disease (AD) and AD related disorders (ADRDs) in ethnic and racial minority populations exist, primarily due to the underrepresentation of minority groups in aging research. Community engagement and outreach is considered one of the most successful strategies to recruiting diverse populations into research. The Dallas Forth-Worth (DFW) metroplex, home to the Health and Aging Brain Study-Health Disparities (HABS-HD), is currently reflective of the future U.S. racial/ethnic population and an ideal location to simultaneously study cognitive aging among African Americans (AA), Mexican Americans (MA; 63% of the U.S. Hispanic population) and non-Hispanic whites (NHW). HABS-HD is the first large-scale, community-based project to simultaneously study each of the AT(N) defined biomarkers, in alignment with the NIA Health Disparities Research Framework. The long-term goal of HABS-HD is to establish population-specific informed precision medicine for novel treatment and prevention strategies as called for in NIA AD+ADRD Research Implementation Milestone 1. For nearly 10 years, HABS-HD has built a network of community ties and relationships using a community-based approach to recruitment. This approach, which emphasized outreach, engagement, and collaboration between the research team and key stakeholders in the community, led to the successful recruitment of 2,000 participants (n=1,000 NHW, 1,000 MA) aged 50 and older and longitudinal follow-ups are underway. Based on UNTHSC Institutional funding, the cohort has expanded to include 1,000 AAs with recruitment to be completed prior to initiation of this U19. As part of the proposed U19, the primary goal of the Core E is to further increase awareness and engagement of diverse communities into research and to provide the outreach infrastructure to comprehensively understand the development and progression of AD and ADRDs across the lifecourse. To address this goal, Core E will address the following Specific Aims: Aim 1: Extend the recruitment of the HABS-HD cohort to ages 30-49 (n=500 per racial/ethnic group), retain existing participants, and recruit new participants to counteract attrition. Aim 2: Generate and disseminate educational materials regarding the importance of brain aging over the lifecourse and the importance of research in diverse communities. Aim 3: In collaboration with all Cores and Projects, continue to monitor and ensure that all HABS-HD activities are conducted in alignment with the NIA Health Disparities Research Framework.