Center for Translational Research on Aging

摘要 Kuakini医学中心(Kuakini)建议发展一个位于夏威夷的多学科生物医学中心 卓越研究奖(Cobre)，用于老龄问题的翻译研究。这个中心将最大限度地利用 来自全州各地的有前途的初级调查人员通过跨机构和跨学科的协作 Kuakini、夏威夷大学约翰·A·伯恩斯医学院(JABSOM)和梅杰 学术研究中心和医学中心。它将跨越机构边界，促进旨在 提高人类健康寿命(健康寿命)和改善与年龄有关的主要疾病，包括 在夏威夷、美国本土和世界各地的人们中，心血管疾病、癌症和痴呆症。 该中心将建立在Kuakini公司50年来由NIH资助的研究的记录的基础上，其 420,000个标本的生物库，以及它在衰老研究中的现有优势，特别是51年的长Kuakini 檀香山心脏计划(Kuakini HHP)和Kuakini檀香山-亚洲老龄化研究(Kuakini Haas)，以及Kuakini HHP后代研究。这将推进翻译老化研究，并培育有意义的解决方案，以实现 与衰老过程相关的疾病和残疾。 我们将通过以下具体目标来实现这一长期目标： 的具体目标1：创建世界级的、创新的、跨学科的翻译研究中心 以现有稀有而珍贵的Kuakini火奴鲁鲁心脏计划为基础的老龄化(CTRA) (Kuakini HHP)及其相关研究、现有Kuakini HHP后代研究和研究 基础设施。 特定目标2-推进衰老的基因组、生物和临床科学，并增强世界 我们建议的中心的阶级性，通过招募有成就的资深科学家来指导有前途的 夏威夷从事跨学科研究和职业发展的初级调查人员。 特定目标3-通过以下方式提升我们中心的能力：i)创建最先进的临床和 翻译核心，以及ii)与其他生物医学研究卓越中心合作。 临床和翻译核心将扩展到强大的流行病学、基因组和临床工作 Kuakini HHP及其相关研究和Kuakini HHP后代研究；使该州的调查人员受益 并促进将基础科学和临床研究成果转化为新的应用和 健康老龄化治疗学。Cobre资金将与机构承诺相结合，以加快 发展卓越的研究成果。该中心将与其他三个总部位于夏威夷的科布雷合作， Cobre小鼠表型核心，以及INBRE资助的生物信息学和生物统计学核心 夏威夷大学。

ABSTRACT Kuakini Medical Center (Kuakini) proposes to develop a multidisciplinary Hawai'i-based Center of Biomedical Research Excellence (COBRE) for translational research on aging. This Center will draw on the most promising junior investigators from across the state with cross-institutional and interdisciplinary collaborative efforts between Kuakini, the University of Hawaii John A. Burns School of Medicine (JABSOM), and major academic research centers and medical centers. It will cross institutional borders to promote research aimed at improving human healthy lifespan (healthspan) and ameliorating major age-related diseases, including cardiovascular diseases, cancer and dementia, in people of Hawaii, the U.S. mainland and around the world. The Center will build upon the strengths of Kuakini's five-decade track record of NIH-funded research, its 420,000-specimen biorepository, and its existing strengths in aging research, notably, the 51-year long Kuakini Honolulu Heart Program (Kuakini HHP) and Kuakini Honolulu-Asia Aging Study (Kuakini HAAS), and Kuakini HHP Offspring Study. This will advance translational aging research and foster meaningful solutions toward the disease and disability associated with the aging process. We will pursue this long-term goal via the following specific aims:  Specific Aim 1: Create a world class, innovative, interdisciplinary Center for Translational Research on Aging (CTRA) by building on the existing rare and valuable Kuakini Honolulu Heart Program (Kuakini HHP) and its related studies, existing Kuakini HHP Offspring Study, and research infrastructure.  Specific Aim 2 - Advance the genomic, biological and clinical science of aging, and enhance the world class character of our proposed Center, by enlisting accomplished senior scientists to mentor promising Hawaii-based junior investigators in interdisciplinary research and career development.  Specific Aim 3 - Elevate the capacity of our Center by: i) creating a state-of-the-art Clinical and Translational Core, and ii) collaborating with other Centers of Biomedical Research Excellence. The Clinical and Translational Core will expand upon the strong epidemiologic, genomic and clinical work of Kuakini HHP and related studies and the Kuakini HHP Offspring Study; benefit investigators in the State of Hawaii and abroad, and foster translation of basic science and clinical findings into novel applications and therapeutics for healthy aging. COBRE funding will be leveraged with institutional commitments to accelerate the development of research excellence. The Center will collaborate with three other Hawaii-based COBREs, the COBRE Mouse Phenotyping Core, and the INBRE-funded Bioinformatics and Biostatistics Core at the University of Hawaii.