Admin-Core-001

行政核心的总体目标是为项目“肺癌病因和风险的综合分析”的所有方面提供领导和一般管理。该核心将负责将科学学科和研究地点整合为统一的跨学科方法。这种方法的重点是与大规模的合作努力，这些努力正在系统地评估吸烟行为和肺癌病因，大规模研究基因变异和对肺癌风险的影响，以及开发和评估为肺癌风险提供信息的生物标记物。为了实现我们的目标，我们的科学议程包括三个相互关联的项目。我们的调查团队是多学科的，建立在我们互补优势的基础上。该核心将负责管理所有项目和核心资源，并将确保遵守所有政府和具体的NIH法规和要求，包括与项目办公室和其他NCI工作人员及时沟通和协商。核心将召开所有必要的会议，包括内部指导委员会的每月会议和外部科学咨询委员会的年度会议。此外，还将组织每月一次的网络研讨会，使具有本提案所依据的各个学科的专门知识的发言者汇聚一堂。该核心的具体目标是：具体目标1.维持和进一步发展流行病学和遗传数据数据库。这一目标支持协调一致的流行病学数据的大型数据库，并为匹配遗传信息的分发提供支持。目标2.为计划项目活动提供综合支持。这一核心的主要功能是确保方案项目关系和沟通的有效运作。目标3：确保计划项目符合所有法规要求。管理核心支持支持研究的协议的开发。它还协调与需要或请求数据传输的DBGaP和其他实体的关系。它还将管理与NCI方案、技术和行政工作人员的所有通信。目标4.提供财政监督和管理。行政核心监督财务管理，并确保及时管理项目和核心之间的财务关系。

The overall goal of the Administrative Core is to provide leadership and general administration related to all aspects of the program project ‘Integrative Analysis of Lung Cancer Etiology and Risk’. This Core will be responsible for integrating the scientific disciplines and study sites into a unified interdisciplinary approach. This approach is focused on working with large-scale collaborative efforts that are systematically evaluating smoking behaviors and lung cancer etiology, large-scale studies of genetic variation and impact on lung cancer risk, and development and evaluation of biomarkers that inform risk for lung cancer development. To achieve our goals, our scientific agenda comprises a series of three inter-related program projects. Our team of investigators is multidisciplinary, building upon our complementary strengths. This Core will be responsible for managing all project and core resources and will ensure compliance with all governmental and specific NIH regulations and requirements, including timely communication and consultation with project offices and other NCI staff. The core will convene all necessary meetings, including monthly meetings of the internal steering committee and annual meeting of the external scientific advisory committee. In addition, monthly webinars will be organized to bring together speakers with expertise in the various disciplines upon which this proposal is composed. The specific aims of this Core are: Specific Aim 1. Maintain and further develop a database for epidemiological and genetic data. This aim supports a large database of harmonized epidemiological data and also provides support for distribution of matching genetic information. Aim 2. Perform Integrative Support for Program Project Activities. The primary function of this core is to ensure the efficient functioning of Program Project relationships and communication. Aim 3. Ensure compliance of the Program Project with all Regulatory Requirements. The administrative core supports the development of protocols that support studies. It also coordinates relationships with dbGAP and other entities for whom data transfers are required or requested. It will also manage all communications with NCI programmatic, technical and administrative staff. Aim 4. Provide fiscal oversight and management. The administrative core oversees financial management and ensures timely management of financial relationships among the Projects and Cores.