Admin-Core-001

管理核心（核心A）摘要管理核心由Jeffrey Myers博士和Vlad Sandulache博士领导，并得到中心管理员Toyin Babarinde博士的支持，是休斯顿获得性耐药研究中心（H-CARR）不可或缺的组成部分。行政核心（核心A）的总体目标是为H-CARR提供关键的集中支持，并确保中心内三个项目和核心以及更广泛的ARTNet社区之间的无缝互动和集成。核心A旨在监测研究活动，并提供稳定和持续的领导，指导该研究中心未来的科学方向。核心A将在关键决策步骤中利用中心咨询小组广泛的科学研究相关经验。行政核心将确保强调基本的机械和转化研究，促进跨学科和项目间的整合，包括协助建立与其他ARTNet中心以及U24 ARTNet协调数据和管理中心（ARTNet CDMC U24）和NCI工作人员的合作。核心A还将全面负责H-CARR的财务和预算管理，包括雇用关键人员，以确保拥有一支高素质、训练有素、管理良好和多样化的工作队伍，从而实现资源的成本效益和有效利用。该核心还将监测科学完整性和对所有机构、州、联邦和NCI法规和要求的总体遵守情况，以及数据完整性的质量保证。核心A的优势在于其完善的计划内，机构内和外部顾问结构，他们都致力于通过持续的审查，咨询和定期会议和建议来支持核心A领导人，以确保强大的科学性能和实现商定的计划目标的进展。在核心A领导人的指导下，核心A还将为研究提供支持和基础设施，促进所有H-CARR研究人员之间清晰开放的沟通，为监管监测和合规活动提供集中资源，并对项目和核心活动以及实现其目标的进展进行定期审查。在核心A领导人的指导下，核心A还将为研究提供支持和基础设施，促进所有H-CARR研究者之间清晰开放的沟通，参与监管监测，以优化头颈癌耐药的基本机制和临床前/转化研究的成功结果。

Administrative Core (Core A) SUMMARY The Administrative Core, led by Dr. Jeffrey Myers and Dr. Vlad Sandulache, and supported by the Center Administrator Dr. Toyin Babarinde, is an indispensable component of the Houston Center for Acquired Resistance Research (H-CARR). The overall objective of the Administrative Core (Core A) is to provide critical centralized support to the H-CARR and ensure seamless interactions and integration between the three projects and cores within the center as well as the broader ARTNet community. Core A is designed to monitor research activity and provide stable and continuous leadership that guides future scientific directions for this Research Center. Core A will leverage the wide-ranging scientific, research related experience of the Center Advisory Group in critical decision-making steps. The Administrative Core will ensure an emphasis on basic mechanistic and translational research and facilitate interdisciplinary and inter-project integration, including assistance in the establishment of collaborations with other ARTNet centers as well as the U24 ARTNet Coordinating Data and Management Center (ARTNet CDMC U24) and NCI staff. Core A will also have overall responsibility for fiscal and budgetary management of the H-CARR, including the employment of key personnel to ensure a highly qualified, well trained, managed, and diverse work force that will enable cost-effective and efficient use of resources. This Core will also monitor scientific integrity and overall compliance with all institutional, state, federal, and NCI regulations and requirements, as well as quality assurance for data integrity. The strength of Core A rest in its well-developed structure of intra-programmatic, intra-institutional, and external advisors who are all dedicated to support Core A Leaders through ongoing review, advice, and periodic meetings and recommendations to ensure robust scientific performance and progress toward the agreed upon programmatic goals. Under the direction of the Core A Leaders, Core A will also provide support and infrastructure for research, facilitate clear and open communications among all H-CARR investigators, provide a centralized resource for regulatory monitoring and compliance activities, and perform scheduled reviews of project and core activities and progress towards their goals. Under the direction of the Core A Leaders, Core A will also provide support and infrastructure for research, facilitate clear and open communications among all H-CARR investigators, engage in regulatory monitoring to optimize the successful outcome of the basic mechanistic and preclinical/translational research in resistance to drug therapy in head and neck cancer.